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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.12 P.888-895


Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier

Author(s):  Zhang Xi-ping, Zhang Jie, Song Qiao-ling, Chen Han-qin

Affiliation(s):  Department of General Surgery, Hangzhou First People’ more

Corresponding email(s):   zxp99688@vip.163.com

Key Words:  Acute pancreatitis (AP), Intestinal mucosa barrier, Microcirculation disturbance, Apoptosis, Inflammatory mediators

Zhang Xi-ping, Zhang Jie, Song Qiao-ling, Chen Han-qin. Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier[J]. Journal of Zhejiang University Science B, 2007, 8(12): 888-895.

@article{title="Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier",
author="Zhang Xi-ping, Zhang Jie, Song Qiao-ling, Chen Han-qin",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier
%A Zhang Xi-ping
%A Zhang Jie
%A Song Qiao-ling
%A Chen Han-qin
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 12
%P 888-895
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0888

T1 - Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier
A1 - Zhang Xi-ping
A1 - Zhang Jie
A1 - Song Qiao-ling
A1 - Chen Han-qin
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 12
SP - 888
EP - 895
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0888

acute pancreatitis (AP) is a common acute abdomen in clinic with a rapid onset and dangerous pathogenetic condition. AP can cause an injury of intestinal mucosa barrier, leading to translocation of bacteria or endotoxin through multiple routes, bacterial translocation (BT), gutorigin endotoxaemia, and secondary infection of pancreatic tissue, and then cause systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS), which are important factors influencing AP’s severity and mortality. Meanwhile, the injury of intestinal mucosa barrier plays a key role in AP’s process. Therefore, it is clinically important to study the relationship between the injury of intestinal mucosa barrier and AP. In addition, many factors such as microcirculation disturbance, ischemical reperfusion injury, excessive release of inflammatory mediators and apoptosis may also play important roles in the damage of intestinal mucosa barrier. In this review, we summarize studies on mechanisms of AP.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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