Full Text:   <3578>

CLC number: R28; R65

On-line Access: 

Received: 2006-06-13

Revision Accepted: 2006-11-28

Crosschecked: 0000-00-00

Cited: 7

Clicked: 6576

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.2 P.147-152


Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Author(s):  ZHANG Xi-ping, LIU Da-ren, SHI Yan

Affiliation(s):  Department of General Surgery, Hangzhou First People’ more

Corresponding email(s):   zxp99688@vip.163.com

Key Words:  Severe acute pancreatitis, Treatment, Traditional Chinese medicine (TCM) monomer

Share this article to: More <<< Previous Article|

ZHANG Xi-ping, LIU Da-ren, SHI Yan. Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis[J]. Journal of Zhejiang University Science B, 2007, 8(2): 147-152.

@article{title="Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis",
author="ZHANG Xi-ping, LIU Da-ren, SHI Yan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis
%A ZHANG Xi-ping
%A LIU Da-ren
%A SHI Yan
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 2
%P 147-152
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0147

T1 - Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis
A1 - ZHANG Xi-ping
A1 - LIU Da-ren
A1 - SHI Yan
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 2
SP - 147
EP - 152
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0147

severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, multiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM) monomers have markedly good effect for treating SAP. Many TCM monomers can inhibit pancreatin, resist inflammation, improve microcirculation and immunoloregulation, etc. to block the pathological progress of SAP in multiple ways, reduce complications and lower mortality with rapid effects. It is significant for enhancing SAP treatment to deeply understand the current situation in TCM monomers for treating SAP and take precious references therein. This article summarizes the treating effects and mechanisms of TCM monomers for SAP in recent years.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Chang, D.M., Gu, Y.J., Zhang, X.C., 2003. The observation of therapeutic effect of Ligustrazine injection on treating 50 case of patients with acute pancreatitis. Acad. Periodical Changchun Coll. Tradit. Chin. Med., 19(1):40-41 (in Chinese).

[2] Chao, H.W., Qi, Q.H., 2003. The study of taxol to induce apoptosis of pancreatic acinar cell and relieve severity of acute pancreatitis. Chin. J. Gen. Surg., 18(5):307-308 (in Chinese).

[3] Chen, X.Q., 1998. New Pharmacology. Publishing Company of People Public Health, Beijing, p.276 (in Chinese).

[4] Fu, X.,Yang, X.F., Zhen, H., Zhou, X.D., 2003. The observation of curative effects on sodium β-aescin treating 26 cases of acute pancreatitis. J. Nanhua Univ., 31(4):479-480 (in Chinese).

[5] Gao, X.S., Chen, F.X., 1990. To use Rhubarb properly on behalf of mankind healthy. J. Integr. Tradit. Western Med., 10(12):754 (in Chinese).

[6] Ge, Z., Zhang, D.S., Hu, Y.L., Wang, Y., 2002. Experimental study on therapeutic effect of pngs and somatostatin for severe acute pancreatitis model in rats. China J. Mod. Med., 12(14):17-19 (in Chinese).

[7] Guan, Y.Y., Chen, K.M., Sun, J.J., 1990. The effection of Sanchinoside to α receptor of vascular smooth muscle in extending pulse and inflow of Ca++. Chin. Pharmacol. Bull., 6(4):229-231 (in Chinese).

[8] He, M.H., 1995. Investagate the effect of phospholipase A2 in leucocyte and its mechanism of tetrandrine. Chin. Pharmacol. Bull., 11(1):53 (in Chinese).

[9] Horsch, S., Walther, C., 2004. Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD)—a review based on randomized, controlled studies. Int. J. Clin. Pharmacol. Ther., 42(2):63-72.

[10] Huang, J.Y., Ma, Q.Y., Sun, Q., Liu, X.M., Xu, J., 2005. Experimental study of resveratrol on severe acute pancreatitis. J. Xi’an Jiaotong Univ., 26(2):163-165 (in Chinese).

[11] Jiang, Z.H., Yu, J.B., Yu, J., 2000. Tetrandrine treat acute hemorrhagic necrotizing pancreatitis. J. Tradit. Chin. Med. Univ. Hunan, 20(1):47-48 (in Chinese).

[12] Jin, C., Ni, Q.X., Zhang, Q.H., Xiang, Y., Zhang, N., Zhang, Y.L., 2000. An experimental study on the immunoregulatory effect of an extract of Tripterygium Wilfordii Hook F in rats with acute necrotizing pancreatitis. Chin. J. Gen. Surg., 15(5):283-285 (in Chinese).

[13] Lou, K.X., Gong, Z.H., Yuan, Y.Z., Tu, S.P., Zhai, Y.Z., Xu, J.Y., 2001. Study on effect of emodin on TGF beta 1 expression in pancreatic tissue of rats suffering from acute pancreatitis. Chin. J. Integr. Tradit. Western Med., 21(6):433-436 (in Chinese).

[14] Ma, X.G., Wang, C.C., Zhu, J.C., 2003. Continuous intravenous instillation of anisodamine as a treatment for severe acute pancreatitis: a controlled study of 60 cases. Chin. J. Pancreatol., 3(3):167-169 (in Chinese).

[15] Men, F.C., 1994. Study progress of Tripterygium Wilfordii and its monomer in antifertility and immunosuppressive action. J. Chin. Tradit. Herbal Drugs, 25(11):607 (in Chinese).

[16] Pan, L., Yuan, Y.Z., Zhang, Y.P., Qiao, M.M., Zhai, Z.K., 2002. Mechanisms of emodin in apoptosis of pancreatic cells in acute pancreatitis in rats. Clin. J. Pancreatol., 12(2):214-217 (in Chinese).

[17] Pietri, S., Maurelli, E., Drieu, K., Culcasi, M., 1997. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J. Mol. Cell. Cardiol., 29(2):733-742.

[18] Qian, Y.H., Gao, S.Z., Yao, Z., 1993. The effection on oxygen free radical of danshen, allopurinol and tetramethyl-pyrazine in extracorporeal circulation. Chin. J. Thorac. Cardiovasc. Surg., 9(3):224-226 (in Chinese).

[19] Schneider, L.S., DeKosky, S.T., Farlow, M.R., Tariot, P.N., Hoerr, R., Kieser, M., 2005. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s type. Curr. Alzheimer Res., 2(5):541-551.

[20] Tang, C., 1986. Effect of endotoxin on lipid peroxidation in liposomes and the salutary effects of anisodamine and α-tocophero. Circ. Shock, 18(3):354-359 (in Chinese).

[21] Tian, J., Song, S.G., Wang, Y.L., Chen, Z.W., Zhao, W.Z., 2006. Effect of rutoside on phospholipase A2 and Ca2+ in murine acute pancreatitis. Anhui Med. Pharm. J., 10(2):88-90 (in Chinese).

[22] Wu, J.X., Xu, J.Y., Yuan, Y.Z., 1997. Effect of emodin and stilamin on pancreatic ischemiain acute hemorrhagic necrotizing pancreatitis and its mechanism. Chin. Crit. Care Med., 9(7):405-408 (in Chinese).

[23] Xiong, J.W., Shen, W.L., Chen, G.Z., Wen, J., Liu, S.J., 2004. Changes of nitric oxide in acute necrotizing pancreatitis and therapeutic action of sanqizongdai. Chin. J. Surg. Integr. Tradit. Western Med., 10(3):192-194 (in Chinese).

[24] Xu, J.H., 2001. Scutellarin injections of Yunan treat 67 cases of patients with cerbral infaction. Chin. J. Integr. Tradit. Western Med., 21(3):228 (in Chinese).

[25] Yamaguchi, Y., Matsumura, F., Liang, J., Okabe, K., Matsuda, T., Ohshiro, H., Ishihara, K., Akizuki, E., Yamada, S., Ogawa, M., 1999. Platelet-activating factor antagonist (TCV-309) attenuates the priming effects of bronchoalveolar macrophages in cerulein-induced pancreatitis rats. Pancreas, 18(4):355-363.

[26] Yu, B.R., Tan, Y.H., 1992. The cytoprotection and calcium rivalry of Anisodamine. Chin. Pharmacol. Bull., 8:257-261 (in Chinese).

[27] Yu, D.S., Fen, J.P., Li, H.F., 2000. Scutellarin treat 30 case of patients with acute pancreatitis. World Chin. J. Digestol., 8(8):112 (in Chinese).

[28] Zeybek, N., Gorgulu, S., Yagci, G., Serdar, M., 2003. The effects of Gingko biloba extract (EGb 761) on experimental acute pancreatitis. J. Surg. Res., 115(2):286-293.

[29] Zhang, M., 1993. The vulnerating effect of PAF in rabbits with inhalation injury by smog and prevention and therapeutic effect of tetrandrine. Chin. J. Exp. Surg., 10(4):156 (in Chinese).

[30] Zhang, J.P., Xu, J.L., Xu, L.F., Zhang, P., 2004. Effects of EGb on intestinal mucosal barrier function in acute severe pancreatitis of rats. Jiangsu Med., 30:18-20 (in Chinese).

[31] Zhang, S.J., Zhai, W.L., Zhao, Y.F., Zhu, C.J., Deng, Y.Z., 2005. Triptolide treatment of severe acute pancreatitis in rats. World Chin. J. Digestol., 13(8):997-1001 (in Chinese).

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE