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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.3 P.193~202

10.1631/jzus.B0820179


Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice


Author(s):  Xi-ping ZHANG, Guang-hua FENG, Jie ZHANG, Yang CAI, Hua TIAN, Xiao-feng ZHANG, Yi-feng ZHOU, Zhi-wei WANG, Ke-yi WANG

Affiliation(s):  Department of General Surgery; more

Corresponding email(s):   zxp99688@vip.163.com

Key Words:  Salvia miltiorrhizae, Traditional Chinese medicine, Severe acute pancreatitis (SAP), Obstructive jaundice (OJ), Heart


Xi-ping ZHANG, Guang-hua FENG, Jie ZHANG, Yang CAI, Hua TIAN, Xiao-feng ZHANG, Yi-feng ZHOU, Zhi-wei WANG, Ke-yi WANG. Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice[J]. Journal of Zhejiang University Science B, 2009, 10(3): 193~202.

@article{title="Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice",
author="Xi-ping ZHANG, Guang-hua FENG, Jie ZHANG, Yang CAI, Hua TIAN, Xiao-feng ZHANG, Yi-feng ZHOU, Zhi-wei WANG, Ke-yi WANG",
journal="Journal of Zhejiang University Science B",
volume="10",
number="3",
pages="193~202",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820179"
}

%0 Journal Article
%T Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice
%A Xi-ping ZHANG
%A Guang-hua FENG
%A Jie ZHANG
%A Yang CAI
%A Hua TIAN
%A Xiao-feng ZHANG
%A Yi-feng ZHOU
%A Zhi-wei WANG
%A Ke-yi WANG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 3
%P 193~202
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820179

TY - JOUR
T1 - Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice
A1 - Xi-ping ZHANG
A1 - Guang-hua FENG
A1 - Jie ZHANG
A1 - Yang CAI
A1 - Hua TIAN
A1 - Xiao-feng ZHANG
A1 - Yi-feng ZHOU
A1 - Zhi-wei WANG
A1 - Ke-yi WANG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 3
SP - 193
EP - 202
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820179


Abstract: 
Objective: To investigate the therapeutic effects and mechanisms of Salvia miltiorrhizae (Danshen) in the treatment of severe acute pancreatitis (SAP)- or obstructive jaundice (OJ)-induced heart injury. Methods: A total of 288 rats were used for SAP- (n=108) and OJ-associated (n=180) experiments. The rats were randomly divided into sham-operated, model control, and Salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3, 6 and 12 h subgroups (n=12), whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups (n=15). At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase A2 (PLA2) in blood, and pathological changes of the hearts were investigated. Results: The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but not significantly (P>0.05). The contents of endotoxin (at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively) and PLA2 (at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively) in the treated group were significantly lower than those in the model control group (P<0.01 and P<0.001, respectively). Besides, myocardial pathological injuries were mitigated in SAP and OJ rats. Conclusion: In this study, we found that Salvia miltiorrhizae improved myocardial pathological changes, reduced the content of PLA2 in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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