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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.7 P.507~511

http://doi.org/10.1631/jzus.2007.B0507


Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography


Author(s):  ZHANG Yan-zhen, ZHOU Yan-chun, LIU Li, ZHU Yan

Affiliation(s):  Department of Stomatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   zyz85@hotmail.com, zhuyan@zju.edu.cn

Key Words:  Ion chromatography, Anions, Gargles, Monofluorophosphate, Sorbate, Saccharin


ZHANG Yan-zhen, ZHOU Yan-chun, LIU Li, ZHU Yan. Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography[J]. Journal of Zhejiang University Science B, 2007, 8(7): 507~511.

@article{title="Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography",
author="ZHANG Yan-zhen, ZHOU Yan-chun, LIU Li, ZHU Yan",
journal="Journal of Zhejiang University Science B",
volume="8",
number="7",
pages="507~511",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0507"
}

%0 Journal Article
%T Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography
%A ZHANG Yan-zhen
%A ZHOU Yan-chun
%A LIU Li
%A ZHU Yan
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 7
%P 507~511
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0507

TY - JOUR
T1 - Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography
A1 - ZHANG Yan-zhen
A1 - ZHOU Yan-chun
A1 - LIU Li
A1 - ZHU Yan
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 7
SP - 507
EP - 511
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0507


Abstract: 
Simple, reliable and sensitive analytical methods to determine anticariogenic agents, preservatives, and artificial sweeteners contained in commercial gargles are necessary for evaluating their effectiveness, safety, and quality. An ion chromatography (IC) method has been described to analyze simultaneously eight anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate (anticariogenic agents), sorbate (a preservative), and saccharin (an artificial sweetener) in gargles. In this IC system, we applied a mobile phased gradient elution with KOH, separation by IonPac AS18 columns, and suppressed conductivity detection. Optimized analytical conditions were further evaluated for accuracy. The relative standard deviations (RSDs) of the inter-day’s retention time and peak area of all species were less than 0.938% and 8.731%, respectively, while RSDs of 5-day retention time and peak area were less than 1.265% and 8.934%, respectively. The correlation coefficients for targeted analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions were 90%~102.5%. We concluded that the method can be applied for comprehensive evaluation of commercial gargles.

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Reference

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[8] Stookey, G.K., DePaola, P.F., Featherstone, J.D., Fejerskov, O., Moller, I.J., Rotberg, S., Stephen, K.W., Wefel, J.S., 1993. A critical review of the relative anticaries efficacy of sodium fluoride and sodium monofluorophosphate dentifrices. Caries Res., 27(4):337-360.

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