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Received: 2008-06-01

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Journal of Zhejiang University SCIENCE A 2009 Vol.10 No.5 P.758~766


Simulated moving bed separation of tocopherol homologues: simulation and experiments

Author(s):  Yu-bin LÜ,, Bao-gen SU, Yi-wen YANG, Qi-long REN, Ping-dong WU

Affiliation(s):  National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   lvyubin2001@zju.edu.cn, subg@zju.edu.cn

Key Words:  Simulated moving bed (SMB), Separation, Modeling, Simulation, Tocopherol homologues

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Yu-bin LÜ, Bao-gen SU, Yi-wen YANG, Qi-long REN, Ping-dong WU. Simulated moving bed separation of tocopherol homologues: simulation and experiments[J]. Journal of Zhejiang University Science A, 2009, 10(5): 758~766.

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journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

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%T Simulated moving bed separation of tocopherol homologues: simulation and experiments
%A Yu-bin LÜ
%A Bao-gen SU
%A Yi-wen YANG
%A Qi-long REN
%A Ping-dong WU
%J Journal of Zhejiang University SCIENCE A
%V 10
%N 5
%P 758~766
%@ 1673-565X
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A0850108

T1 - Simulated moving bed separation of tocopherol homologues: simulation and experiments
A1 - Yu-bin LÜ
A1 -
A1 - Bao-gen SU
A1 - Yi-wen YANG
A1 - Qi-long REN
A1 - Ping-dong WU
J0 - Journal of Zhejiang University Science A
VL - 10
IS - 5
SP - 758
EP - 766
%@ 1673-565X
Y1 - 2009
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.A0850108

Chromatograms of tocopherol homologues were obtained by a column of analytical size (inner diameter (ID) 0.46 cm cm×10 cm) packed with silica gel. Adsorption isotherms and film mass-transfer coefficient were estimated from the chromatograms by using a general rate model, which considers axial dispersion, external mass-transfer and intraparticle diffusion. Based on the obtained isotherms and mass-transfer coefficient, the separation process of tocopherol homologues on simulated moving bed (SMB) was simulated using the same model. According to the simulated results, a mixture of α-, γ-, δ-tocopherols and other impurities was separated on an SMB equipment. The SMB equipment was composed of 8 columns of ID 2 cm×10 cm, with 2 columns in each section. The solid phase was silica gel, and the mobile phase was n-hexane/2-propanol (99/1 by volume). γ- and δ-tocopherols of purity greater than 98% were obtained with recovery greater than 98%. The effects of operating conditions (flow rates and switching time) on the performance of SMB were studied by both simulation and experiments. It was found that all the simulation results were quite close to the experimental results. We conclude that process development and optimization of operating conditions of SMB by simulation are feasible.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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