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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.11 P.847-852


Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression

Author(s):  Zhong-zheng ZHU, Bing LIU, Ai-zhong WANG, Hang-ruo JIA, Xia-xiang JIN, Xiang-lei HE, Li-fang HOU, Guan-shan ZHU

Affiliation(s):  Department of Pathology, No. 113 Hospital of People’ more

Corresponding email(s):   zzzhu1170@yahoo.com

Key Words:  Colorectal cancer, p53, Genetic polymorphism, Liver metastases, Overexpression

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Zhong-zheng ZHU, Bing LIU, Ai-zhong WANG, Hang-ruo JIA, Xia-xiang JIN, Xiang-lei HE, Li-fang HOU, Guan-shan ZHU. Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression[J]. Journal of Zhejiang University Science B, 2008, 9(11): 847-852.

@article{title="Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression",
author="Zhong-zheng ZHU, Bing LIU, Ai-zhong WANG, Hang-ruo JIA, Xia-xiang JIN, Xiang-lei HE, Li-fang HOU, Guan-shan ZHU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression
%A Zhong-zheng ZHU
%A Bing LIU
%A Ai-zhong WANG
%A Hang-ruo JIA
%A Xia-xiang JIN
%A Xiang-lei HE
%A Li-fang HOU
%A Guan-shan ZHU
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 11
%P 847-852
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820100

T1 - Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression
A1 - Zhong-zheng ZHU
A1 - Bing LIU
A1 - Ai-zhong WANG
A1 - Hang-ruo JIA
A1 - Xia-xiang JIN
A1 - Xiang-lei HE
A1 - Li-fang HOU
A1 - Guan-shan ZHU
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 11
SP - 847
EP - 852
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820100

Objective: To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases. Methods: The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. Results: The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases (P=0.075). Carriers of the 72R allele had a 2.25-fold (95% CI (confidence interval)=1.05~4.83) increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold (95% CI=1.02~11.72) and a 1.05-fold (95% CI=0.36~3.08) increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion: These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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