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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.9 P.639~647

10.1631/jzus.B0920130


High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors


Author(s):  Xiang JI, Jing-feng BAI, Guo-feng SHEN, Ya-zhu CHEN

Affiliation(s):  Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; more

Corresponding email(s):   shenguofeng@sjtu.edu.cn

Key Words:  High-intensity focused ultrasound (HIFU), Spherical phased array, Large scale, Deep tissue ablation


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Xiang JI, Jing-feng BAI, Guo-feng SHEN, Ya-zhu CHEN. High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors[J]. Journal of Zhejiang University Science B, 2009, 10(9): 639~647.

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volume="10",
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pages="639~647",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0920130"
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%T High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors
%A Xiang JI
%A Jing-feng BAI
%A Guo-feng SHEN
%A Ya-zhu CHEN
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 9
%P 639~647
%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920130

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T1 - High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors
A1 - Xiang JI
A1 - Jing-feng BAI
A1 - Guo-feng SHEN
A1 - Ya-zhu CHEN
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 9
SP - 639
EP - 647
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0920130


Abstract: 
Under some circumstances surgical resection is feasible in a low percentage for the treatment of deep tumors. Nevertheless, high-intensity focused ultrasound (HIFU) is beginning to offer a potential noninvasive alternative to conventional therapies for the treatment of deep tumors. In our previous study, a large scale spherical HIFU-phased array was developed to ablate deep tumors. In the current study, taking into account the required focal depth and maximum acoustic power output, 90 identical circular PZT-8 elements (diameter=1.4 cm and frequency=1 MHz) were mounted on a spherical shell with a radius of curvature of 18 cm and a diameter of 21 cm. With the developed array, computer simulations and ex vivo experiments were carried out. The simulation results theoretically demonstrate the ability of the array to focus and steer in the specified volume (a 2 cm×2 cm×3 cm volume) at the focal depth of 15 to 18 cm. Ex vivo experiment results also verify the capability of the developed array to ablate deep target tissue by either moving single focal point or generating multiple foci simultaneously.

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Reference

[1] Daum, D.R., Hynynen, K., 1999a. A 256-element ultrasonic phased array system for the treatment of large volumes of deep seated tissue. IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 46(5):1254-1268.

[2] Daum, D.R., Hynynen, K., 1999b. Theoretical design of a spherically sectioned phased array for ultrasound surgery of the liver. Eur. J. Ultrasound, 9(1):61-69.

[3] Diederich, C.J., Stafford, R.J., Nau, W.H., Burdette, E.C., Price, R.E., Hazle, J.D., 2004. Transurethral ultrasound applicators with directional heating patterns for prostate thermal therapy: in vivo evaluation using magnetic resonance thermometry. Med. Phys., 31(2):405-413.

[4] Ebbini, E.S., Cain, C.A., 1989. Multiple-focus ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia. IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 36(5):540-548.

[5] Ebbini, E.S., Cain, C.A., 1991. A spherical-section ultrasound phased array applicator for deep localized hyperthermia. IEEE Trans. Biomed. Eng., 38(7):634-643.

[6] Filonenko, E.A., Gavrilov, L.R., Khokhlova, V.A., Hand, J.W., 2004. Heating of biological tissues by two-dimensional phased arrays with random and regular element distributions. Acoust. Phys., 50(2):222-231.

[7] Gavrilov, L.R., Hand, J.W., 2000. A theoretical assessment of the relative performance of spherical phased arrays for ultrasound surgery. IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 47(1):125-139.

[8] Goss, S.A., Frizzell, L.A., Kouzmanoff, J.T., Barich, J.M., Yang, J.M., 1996. Sparse random ultrasound phased array for focal surgery. IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 43(6):1111-1121.

[9] Hutchins, D.A., Mair, H.D., Puhach, P.A., Osei, A.J., 1986. Continuous-wave pressure fields of ultrasonic transducers. J. Acoust. Soc. Am., 80(1):1-12.

[10] Kennedy, J.E., 2005. High-intensity focused ultrasound in the treatment of solid tumours. Nat. Rev. Cancer, 5(4): 321-327.

[11] Kennedy, J.E., Wu, F., ter Haar, G.R., Gleeson, F.V., Phillips, R.R., Middleton, M.R., Cranston, D., 2004. High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics, 42(1-9):931-935.

[12] Li, G.W., Xiong, B., Chen, Y.Z., 2001. Ultrasound spherical phased-array and the effect of phased and magnitude precision. Shanghai Jiaotong Daxue Xuebao, 35(9): 1412-1414 (in Chinese).

[13] Lu, M.Z., Wang, X.D., Wan, M.X., Feng, Y., Xu, F., Zhong, H., Tan, J.W., 2008. Image-guided 256-element phased-array focused ultrasound surgery. IEEE Eng. Med. Biol. Mag., 27(5):84-90.

[14] N′Djin, W.A., Melodelima, D., Parmentier, H., Chesnais, S., Rivoire, M., Chapelon, J.Y., 2008. Utility of a tumor-mimic model for the evaluation of the accuracy of HIFU treatments. Results of in vitro experiments in the liver. Ultrasound Med. Biol., 34(12):1934-1943.

[15] Pernot, M., Aubry, J.F., Tanter, M., Marquet, F., Montaldo, G., Boch, A.L., Kujas, M., Seilhean, D., Fink, M., 2007. High Power Phased Array Prototype for Clinical High Intensity Focused Ultrasound: Applications to Transcostal and Transcranial Therapy. 29th Annual International IEEE EMBS Conference, Lyon, France. IEEE, USA, p.234-237.

[16] Steinberg, B.D., 1976. Principles of Aperture and Array System Design. Wiley, New York.

[17] Zhang, C.X., Chen, Y.Z., 2007. Investigation of a spherical-section ultrasound phased array for hepatic ablation. J. Zhejiang Univ. Sci. A, 8(8):1237-1245.

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