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Received: 2009-05-05

Revision Accepted: 2009-07-22

Crosschecked: 2009-08-10

Cited: 12

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.9 P.639~647


High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors

Author(s):  Xiang JI, Jing-feng BAI, Guo-feng SHEN, Ya-zhu CHEN

Affiliation(s):  Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; more

Corresponding email(s):   shenguofeng@sjtu.edu.cn

Key Words:  High-intensity focused ultrasound (HIFU), Spherical phased array, Large scale, Deep tissue ablation

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Xiang JI, Jing-feng BAI, Guo-feng SHEN, Ya-zhu CHEN. High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors[J]. Journal of Zhejiang University Science B, 2009, 10(9): 639~647.

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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920130

T1 - High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors
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A1 - Jing-feng BAI
A1 - Guo-feng SHEN
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0920130

Under some circumstances surgical resection is feasible in a low percentage for the treatment of deep tumors. Nevertheless, high-intensity focused ultrasound (HIFU) is beginning to offer a potential noninvasive alternative to conventional therapies for the treatment of deep tumors. In our previous study, a large scale spherical HIFU-phased array was developed to ablate deep tumors. In the current study, taking into account the required focal depth and maximum acoustic power output, 90 identical circular PZT-8 elements (diameter=1.4 cm and frequency=1 MHz) were mounted on a spherical shell with a radius of curvature of 18 cm and a diameter of 21 cm. With the developed array, computer simulations and ex vivo experiments were carried out. The simulation results theoretically demonstrate the ability of the array to focus and steer in the specified volume (a 2 cm×2 cm×3 cm volume) at the focal depth of 15 to 18 cm. Ex vivo experiment results also verify the capability of the developed array to ablate deep target tissue by either moving single focal point or generating multiple foci simultaneously.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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