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CLC number: R581.3

On-line Access: 2012-09-04

Received: 2011-11-08

Revision Accepted: 2012-04-28

Crosschecked: 2012-08-14

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.9 P.707-716

http://doi.org/10.1631/jzus.B1100342


Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules


Author(s):  Yu-rong Hong, Yu-lian Wu, Zhi-yan Luo, Ning-bo Wu, Xue-ming Liu

Affiliation(s):  Department of Ultrasound, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   Wuyulian@medmail.com.cn

Key Words:  Ultrasound, Thyroid nodules, Sonoelastography, Nodule size


Yu-rong Hong, Yu-lian Wu, Zhi-yan Luo, Ning-bo Wu, Xue-ming Liu. Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules[J]. Journal of Zhejiang University Science B, 2012, 13(9): 707-716.

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author="Yu-rong Hong, Yu-lian Wu, Zhi-yan Luo, Ning-bo Wu, Xue-ming Liu",
journal="Journal of Zhejiang University Science B",
volume="13",
number="9",
pages="707-716",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100342"
}

%0 Journal Article
%T Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules
%A Yu-rong Hong
%A Yu-lian Wu
%A Zhi-yan Luo
%A Ning-bo Wu
%A Xue-ming Liu
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 9
%P 707-716
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100342

TY - JOUR
T1 - Impact of nodular size on the predictive values of gray-scale, color-Doppler ultrasound, and sonoelastography for assessment of thyroid nodules
A1 - Yu-rong Hong
A1 - Yu-lian Wu
A1 - Zhi-yan Luo
A1 - Ning-bo Wu
A1 - Xue-ming Liu
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 9
SP - 707
EP - 716
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100342


Abstract: 
Objective: To define the roles of gray-scale, color-Doppler ultrasound, and sonoelastography for the assessment of thyroid nodule to determine whether nodule size affects the differential diagnosis of benign and malignant. Methods: A total of 243 consecutive subjects (214 women, 29 men) with 329 thyroid nodules were examined by gray-scale, color-Doppler ultrasound, and sonoelastography in this prospective study. All patients underwent surgery and the final diagnosis was obtained from histopathological examination. Results: Three hundred and twenty-nine nodules (208 benign, 121 malignant) were divided into small (SNs, 5–10 mm, n=137) and large (LNs, >10 mm, n=192) nodules. Microcalcifications were more frequent in malignant LNs than in malignant SNs, but showed no significant difference between benign LNs and SNs. Poorly-circumscribed margins were not significantly different between malignant SNs and LNs, but were less frequent in benign LNs than in benign SNs. Among all nodules, marked intranodular vascularity was more frequent in LNs than in SNs. By comparison, shape ratio of anteroposterior to transverse dimensions (A/T) ≥1 was less frequent in LNs than in SNs. Otherwise, among all nodules, marked hypoechogenicity and elasticity score of 4–6 showed no significant difference between LNs and SNs. Conclusions: The predictive values of microcalcifications, nodular margins, A/T ratio, and marked intranodular vascularity depend on nodule size, but the predictive values of echogenicity and elastography do not.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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