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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.6 P.428-435

http://doi.org/10.1631/jzus.B1000285


HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations


Author(s):  Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu

Affiliation(s):  Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China, Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan

Corresponding email(s):   tokunaga@m.u-tokyo.ac.jp, chujy08@gmail.com

Key Words:  Human leukocyte antigen (HLA) alleles, Haplotypes, Zhuang population


Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu. HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations[J]. Journal of Zhejiang University Science B, 2011, 12(6): 428-435.

@article{title="HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations",
author="Li Shi, Xiao-qin Huang, Lei Shi, Yu-fen Tao, Yu-feng Yao, Liang Yu, Ke-qin Lin, Wen Yi, Hao Sun, Katsushi Tokunaga, Jia-you Chu",
journal="Journal of Zhejiang University Science B",
volume="12",
number="6",
pages="428-435",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000285"
}

%0 Journal Article
%T HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations
%A Li Shi
%A Xiao-qin Huang
%A Lei Shi
%A Yu-fen Tao
%A Yu-feng Yao
%A Liang Yu
%A Ke-qin Lin
%A Wen Yi
%A Hao Sun
%A Katsushi Tokunaga
%A Jia-you Chu
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 6
%P 428-435
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000285

TY - JOUR
T1 - HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations
A1 - Li Shi
A1 - Xiao-qin Huang
A1 - Lei Shi
A1 - Yu-fen Tao
A1 - Yu-feng Yao
A1 - Liang Yu
A1 - Ke-qin Lin
A1 - Wen Yi
A1 - Hao Sun
A1 - Katsushi Tokunaga
A1 - Jia-you Chu
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 6
SP - 428
EP - 435
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000285


Abstract: 
A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A*11:01, A*02:07, A*24:02, A*02:03, and A*33:03 on A loci, B*15:02, B*58:01, B*46:01, and B*13:01 on B loci, C*03:04, C*08:01, C*01:02, C*03:02, and C*07:02 on C loci, and DRB1*15:01, DRB1*16:02, DRB1*14:01, DRB1*15:02, and DRB1*03:01 on the DRB1 loci were >10%. The A*33:03-C*03:02-B*58:01-DRB1*03:01 and A*02:07-C*01:02-B*46:01-DRB1*14:01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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