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On-line Access: 2013-11-04

Received: 2013-01-27

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Crosschecked: 2013-10-03

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.11 P.1033-1040

http://doi.org/10.1631/jzus.B1300030


Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy


Author(s):  Fang Liu, Min Wu, Yan-huan Feng, Hui Zhong, Tian-lei Cui, You-qun Huang, Ya-ping Liang, Yong-shu Diao, Li Zang, Ling Li, Jing Zang, Hong-yu Qiu, Song-min Huang, Ping Fu

Affiliation(s):  Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China

Corresponding email(s):   liufangfh@163.com, fupinghx@163.com

Key Words:  Short-term blood pressure variability, Diabetic nephropathy, Glycated hemoglobin (HbA1c), Hypertension, Glycaemic control


Fang Liu, Min Wu, Yan-huan Feng, Hui Zhong, Tian-lei Cui, You-qun Huang, Ya-ping Liang, Yong-shu Diao, Li Zang, Ling Li, Jing Zang, Hong-yu Qiu, Song-min Huang, Ping Fu. Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy[J]. Journal of Zhejiang University Science B, 2013, 14(11): 1033-1040.

@article{title="Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy",
author="Fang Liu, Min Wu, Yan-huan Feng, Hui Zhong, Tian-lei Cui, You-qun Huang, Ya-ping Liang, Yong-shu Diao, Li Zang, Ling Li, Jing Zang, Hong-yu Qiu, Song-min Huang, Ping Fu",
journal="Journal of Zhejiang University Science B",
volume="14",
number="11",
pages="1033-1040",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300030"
}

%0 Journal Article
%T Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy
%A Fang Liu
%A Min Wu
%A Yan-huan Feng
%A Hui Zhong
%A Tian-lei Cui
%A You-qun Huang
%A Ya-ping Liang
%A Yong-shu Diao
%A Li Zang
%A Ling Li
%A Jing Zang
%A Hong-yu Qiu
%A Song-min Huang
%A Ping Fu
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 11
%P 1033-1040
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300030

TY - JOUR
T1 - Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy
A1 - Fang Liu
A1 - Min Wu
A1 - Yan-huan Feng
A1 - Hui Zhong
A1 - Tian-lei Cui
A1 - You-qun Huang
A1 - Ya-ping Liang
A1 - Yong-shu Diao
A1 - Li Zang
A1 - Ling Li
A1 - Jing Zang
A1 - Hong-yu Qiu
A1 - Song-min Huang
A1 - Ping Fu
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 11
SP - 1033
EP - 1040
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300030


Abstract: 
The aim of this study was to understand the characteristics of blood pressure (BP) variability in subjects with diabetic nephropathy (DN), and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease (CKD)-hypertensive patients without diabetes (NDN group) and sixty type 2 diabetic patients with overt DN (DN group) were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring (ABPM). Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group [(12.23±3.66) vs. (10.74±3.83) mmHg, P<0.05; (11.23±4.82) vs. (9.48±3.69) mmHg, P<0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin (HbA1c) level: Group A (HbA1c<7%) and Group B (HbA1c≥7%), and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP variability (P<0.001, P<0.001, P<0.05, and P<0.001, respectively). Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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