CLC number: R742.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-06-16
Cited: 7
Clicked: 4795
Ying Zhang, Yu-xin Zheng, Jun-ming Zhu, Jian-min Zhang, Zhe Zheng. Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis[J]. Journal of Zhejiang University Science B, 2015, 16(7): 611-621.
@article{title="Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis",
author="Ying Zhang, Yu-xin Zheng, Jun-ming Zhu, Jian-min Zhang, Zhe Zheng",
journal="Journal of Zhejiang University Science B",
volume="16",
number="7",
pages="611-621",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500021"
}
%0 Journal Article
%T Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis
%A Ying Zhang
%A Yu-xin Zheng
%A Jun-ming Zhu
%A Jian-min Zhang
%A Zhe Zheng
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 7
%P 611-621
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500021
TY - JOUR
T1 - Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis
A1 - Ying Zhang
A1 - Yu-xin Zheng
A1 - Jun-ming Zhu
A1 - Jian-min Zhang
A1 - Zhe Zheng
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 7
SP - 611
EP - 621
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500021
Abstract: Objective: The aim of our meta-analysis was to assess the effects of antiepileptic drugs on bone mineral density and bone metabolism in epileptic children. Methods: Searches of PubMed and Web of Science were undertaken to identify studies evaluating the association between antiepileptic drugs and bone mineral density and bone metabolism. Results: A total of 22 studies with 1492 subjects were included in our research. We identified: (1) a reduction in bone mineral density at lumbar spine (standardized mean difference (SMD)=−0.30, 95% confidence interval (CI) [−0.61, −0.05]), trochanter (mean difference (MD)=−0.07, 95% CI [−0.10, −0.05]), femoral neck (MD=−0.05, 95% CI [−0.09, −0.02]), and total body bone mineral density (MD=−0.33, 95% CI [−0.51, −0.15]); (2) a reduction in 25-hydroxyvitamin D (MD=−3.37, 95% CI [−5.94, −0.80]) and an increase in serum alkaline phosphatase (SMD=0.71, 95% CI [0.38, 1.05]); (3) no significant changes in serum parathyroid hormone, calcium, or phosphorus. Conclusions: Our meta-analysis suggests that treatment with antiepileptic drugs may be associated with decreased bone mineral density in epileptic children.
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