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 ORCID:

Yu YUAN

https://orcid.org/0000-0003-1032-6330

Jun ZOU

https://orcid.org/0000-0001-6036-8067

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.7 P.529-546

http://doi.org/10.1631/jzus.B2100958


Co-regulation of circadian clock genes and microRNAs in bone metabolism


Author(s):  Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, Jun ZOU

Affiliation(s):  School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China; more

Corresponding email(s):   junzou@sus.edu.cn, yuanyumail@126.com

Key Words:  Circadian rhythm, Circadian clock gene, MicroRNAs, Bone metabolism


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Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, Jun ZOU. Co-regulation of circadian clock genes and microRNAs in bone metabolism[J]. Journal of Zhejiang University Science B, 2022, 23(7): 529-546.

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pages="529-546",
year="2022",
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doi="10.1631/jzus.B2100958"
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%0 Journal Article
%T Co-regulation of circadian clock genes and microRNAs in bone metabolism
%A Tingting LI
%A Shihua ZHANG
%A Yuxuan YANG
%A Lingli ZHANG
%A Yu YUAN
%A Jun ZOU
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%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100958

TY - JOUR
T1 - Co-regulation of circadian clock genes and microRNAs in bone metabolism
A1 - Tingting LI
A1 - Shihua ZHANG
A1 - Yuxuan YANG
A1 - Lingli ZHANG
A1 - Yu YUAN
A1 - Jun ZOU
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 7
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%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100958


Abstract: 
Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation, mediated by osteoclasts and osteoblasts. It is widely recognized that circadian clock genes can regulate bone metabolism. In recent years, the regulation of bone metabolism by non-coding RNAs has become a hotspot of research. microRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism, including circadian clock genes. However, research in this field has been conducted only in recent years and the mechanisms involved are not yet well established. Recent studies have focused on how to target circadian clock genes to treat some diseases, such as autoimmune diseases, but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases. Therefore, in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.

生物钟基因与microRNAs共同调控骨代谢的研究进展

李婷婷1,2,张士花3,杨雨轩2,张玲莉2,元宇1,邹军2
1广州体育学院运动与健康学院,中国广州市,510500
2上海体育学院运动科学学院,中国上海市,200438
3山东体育学院研究生教育学院,中国济南市,250102
概要:哺乳动物的骨骼从胚胎阶段开始就不断地进行新陈代谢,骨骼健康状态的维持依赖于破骨细胞和成骨细胞介导的骨吸收和骨形成之间的动态平衡。人们普遍认为,生物钟基因可以调节骨代谢。近年来,非编码RNAs对骨代谢的调控已成为研究热点。MicroRNAs可以通过靶向与骨代谢相关的关键因素参与骨的分解代谢和合成代谢,其中包括生物钟基因。然而,这一领域的研究在最近几年才开始进行,所涉及的机制尚未明晰。最近的研究集中在如何靶向生物钟基因来治疗一些疾病(如自身免疫性疾病),但少有人关注生物钟基因和microRNAs在骨代谢疾病中的共同调控问题。因此,本文对生物钟基因和microRNAs共同调控骨代谢的研究进展进行了回顾,旨在为预防和治疗骨代谢疾病(如骨质疏松症)提供新的思路。

关键词:昼夜节律;生物钟基因;MicroRNAs;骨代谢

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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