Full Text:   <818>

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CLC number: R493

On-line Access: 2016-07-06

Received: 2015-12-02

Revision Accepted: 2016-03-31

Crosschecked: 2016-06-23

Cited: 1

Clicked: 1446

Citations:  Bibtex RefMan EndNote GB/T7714


Qing-ping Tang


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.7 P.493-502


STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats

Author(s):  Qing-ping Tang, Qin Shen, Li-xiang Wu, Xiang-ling Feng, Hui Liu, Bei Wu, Xiao-song Huang, Gai-qing Wang, Zhong-hao Li, Zun-jing Liu

Affiliation(s):  Department of Rehabilitation, Brain Hospital of Hunan Province, Hunan University of Chinese Medicine, Changsha 410007, China; more

Corresponding email(s):   liuzunjing@163.com

Key Words:  Motor training, Signal transducer and activator of transcription 3 (STAT3), Brain-derived neurotrophic factor (BDNF), Protein interacting with C kinase 1 (PICK1), Neural plasticity

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Qing-ping Tang, Qin Shen, Li-xiang Wu, Xiang-ling Feng, Hui Liu, Bei Wu, Xiao-song Huang, Gai-qing Wang, Zhong-hao Li, Zun-jing Liu. STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats[J]. Journal of Zhejiang University Science B, 2016, 17(7): 493-502.

@article{title="STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats",
author="Qing-ping Tang, Qin Shen, Li-xiang Wu, Xiang-ling Feng, Hui Liu, Bei Wu, Xiao-song Huang, Gai-qing Wang, Zhong-hao Li, Zun-jing Liu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats
%A Qing-ping Tang
%A Qin Shen
%A Li-xiang Wu
%A Xiang-ling Feng
%A Hui Liu
%A Bei Wu
%A Xiao-song Huang
%A Gai-qing Wang
%A Zhong-hao Li
%A Zun-jing Liu
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 7
%P 493-502
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500297

T1 - STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats
A1 - Qing-ping Tang
A1 - Qin Shen
A1 - Li-xiang Wu
A1 - Xiang-ling Feng
A1 - Hui Liu
A1 - Bei Wu
A1 - Xiao-song Huang
A1 - Gai-qing Wang
A1 - Zhong-hao Li
A1 - Zun-jing Liu
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 7
SP - 493
EP - 502
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500297

Willed-movement training has been demonstrated to be a promising approach to increase motor performance and neural plasticity in ischemic rats. However, little is known regarding the molecular signals that are involved in neural plasticity following willed-movement training. To investigate the potential signals related to neural plasticity following willed-movement training, littermate rats were randomly assigned into three groups: middle cerebral artery occlusion, environmental modification, and willed-movement training. The infarct volume was measured 18 d after occlusion of the right middle cerebral artery. Reverse transcription-polymerase chain reaction (PCR) and immunofluorescence staining were used to detect the changes in the signal transducer and activator of transcription 3 (STAT3) mRNA and protein, respectively. A chromatin immunoprecipitation was used to investigate whether STAT3 bound to plasticity-related genes, such as brain-derived neurotrophic factor (BDNF), synaptophysin, and protein interacting with C kinase 1 (PICK1). In this study, we demonstrated that STAT3 mRNA and protein were markedly increased following 15-d willed-movement training in the ischemic hemispheres of the treated rats. STAT3 bound to BDNF, PICK1, and synaptophysin promoters in the neocortical cells of rats. These data suggest that the increased STAT3 levels after willed-movement training might play critical roles in the neural plasticity by directly regulating plasticity-related genes.




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