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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2000455


Potential effect of EGCG on the anti-tumour efficacy of metformin in melanoma cells


Author(s):  Anan XU, Jeehyun LEE, Yueling ZHAO, Yuefei WANG, Xiaoli LI, Ping XU

Affiliation(s):  Department of Tea Science, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   zdxp@zju.edu.cn

Key Words:  Epigallocatechin-3-gallate, Metformin, Melanoma, Anti-tumour efficacy


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Anan XU, Jeehyun LEE, Yueling ZHAO, Yuefei WANG, Xiaoli LI, Ping XU. Potential effect of EGCG on the anti-tumour efficacy of metformin in melanoma cells[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000455"
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%A Anan XU
%A Jeehyun LEE
%A Yueling ZHAO
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%A Xiaoli LI
%A Ping XU
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000455

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T1 - Potential effect of EGCG on the anti-tumour efficacy of metformin in melanoma cells
A1 - Anan XU
A1 - Jeehyun LEE
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A1 - Xiaoli LI
A1 - Ping XU
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DOI - 10.1631/jzus.B2000455


Abstract: 
metformin, a first-line drug for type 2 diabetes mellitus, has been recognized as a potential anti-tumour agent in recent years. epigallocatechin-3-gallate (EGCG), as the dominant catechin in green tea, is another promising adjuvant agent for tumour prevention. In the present work, the potential effect of EGCG on the anti-tumour efficacy of metformin in a mouse melanoma cell line (B16F10) was investigated. Results indicated that EGCG and metformin exhibited a synergistic effect on cell viability, migration, and proliferation, as well as STAT3/NF-κB pathway signalling and the production of inflammation cytokines. Meanwhile, the combination showed an antagonistic effect on cell apoptosis and oxidative stress levels. The combination of EGCG and metformin also differentially affected the nucleus (synergism) and cytoplasm (antagonism) of B16F10 cells. Our findings provide new insight into the potential effects of EGCG on the anti-tumour efficacy of metformin in melanoma cells.

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