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On-line Access: 2017-11-06

Received: 2016-10-06

Revision Accepted: 2017-01-27

Crosschecked: 2017-10-20

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Citations:  Bibtex RefMan EndNote GB/T7714


Min-qiang Liu


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.955-962


Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction

Author(s):  Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He

Affiliation(s):  Institute of Anesthesiology, Shenzhen Third Peoples Hospital, Shenzhen 518112, China; more

Corresponding email(s):   szherenliang@163.com

Key Words:  General anesthesia, Fentanyl-induced cough, Slow intravenous fluid line, Alleviate, Induction

Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He. Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction[J]. Journal of Zhejiang University Science B, 2017, 18(11): 955-962.

@article{title="Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction",
author="Min-qiang Liu, Feng-xian Li, Ya-kun Han, Jun-yong He, Hao-wen Shi, Li Liu, Ren-liang He",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction
%A Min-qiang Liu
%A Feng-xian Li
%A Ya-kun Han
%A Jun-yong He
%A Hao-wen Shi
%A Li Liu
%A Ren-liang He
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 11
%P 955-962
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600442

T1 - Administration of fentanyl via a slow intravenous fluid line compared with rapid bolus alleviates fentanyl-induced cough during general anesthesia induction
A1 - Min-qiang Liu
A1 - Feng-xian Li
A1 - Ya-kun Han
A1 - Jun-yong He
A1 - Hao-wen Shi
A1 - Li Liu
A1 - Ren-liang He
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 11
SP - 955
EP - 962
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600442

Objective: fentanyl-induced cough (FIC) is a common complication with a reported incidence from 18.0% to 74.4% during general anesthesia induction. FIC increases the intrathoracic pressure and risks of postoperative nausea and vomiting, yet available treatments are limited. This study was designed to investigate whether administering fentanyl via a slow intravenous fluid line can effectively alleviate FIC during induction of total intravenous general anesthesia. Methods: A total number of 1200 patients, aged 18–64 years, were enrolled, all of whom were American Society of Anesthesiologists (ASA) grade I or II undergoing scheduled surgeries. All patients received total intravenous general anesthesia, which was induced sequentially by midazolam, fentanyl, propofol, and cisatracurium injection. Patients were randomly assigned to receive fentanyl 3.5 μg/kg via direct injection (control group) or via a slow intravenous fluid line. FIC incidence and the severity grades were analyzed with the Mann-Whitney test. Other adverse reactions, such as hypotension, hypertension, bradycardia, tachycardia, hypoxemia, vomiting, and aspiration, during induction were also observed. The online clinical registration number of this study was ChiCTR-IOR-16009025. Results: Compared with the control group, the incidence of FIC was significantly lower in the slow intravenous fluid line group during induction (9.1%, 95% confidence interval (CI):6.7%–11.4% vs. 55.9%, 95% CI: 51.8%–60.0%, P=0.000), as were the severity grades (P=0.000). There were no statistical differences between the two groups with regard to other adverse reactions (P>0.05). Conclusions: The administration of fentanyl via a slow intravenous fluid line can alleviate FIC and its severity during induction for total intravenous general anesthesia. This method is simple, safe, and reliable, and deserves clinical expansion.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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