Full Text:   <807>

Summary:  <169>

CLC number: S852.2

On-line Access: 2018-05-05

Received: 2017-01-26

Revision Accepted: 2017-05-09

Crosschecked: 2018-04-19

Cited: 0

Clicked: 1595

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xing-ting Liu

https://orcid.org/0000-0002-6312-4786

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.5 P.390-399

10.1631/jzus.B1700054


Age-related changes of yolk precursor formation in the liver of laying hens


Author(s):  Xing-ting Liu, Xin Lin, Yu-ling Mi, Wei-dong Zeng, Cai-qiao Zhang

Affiliation(s):  Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   cqzhang@zju.edu.cn

Key Words:  Lipid metabolism, Yolk precursor formation, 17β, -Estradiol, Antioxidant, Hen


Xing-ting Liu, Xin Lin, Yu-ling Mi, Wei-dong Zeng, Cai-qiao Zhang. Age-related changes of yolk precursor formation in the liver of laying hens[J]. Journal of Zhejiang University Science B, 2018, 19(5): 390-399.

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author="Xing-ting Liu, Xin Lin, Yu-ling Mi, Wei-dong Zeng, Cai-qiao Zhang",
journal="Journal of Zhejiang University Science B",
volume="19",
number="5",
pages="390-399",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700054"
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%T Age-related changes of yolk precursor formation in the liver of laying hens
%A Xing-ting Liu
%A Xin Lin
%A Yu-ling Mi
%A Wei-dong Zeng
%A Cai-qiao Zhang
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700054

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T1 - Age-related changes of yolk precursor formation in the liver of laying hens
A1 - Xing-ting Liu
A1 - Xin Lin
A1 - Yu-ling Mi
A1 - Wei-dong Zeng
A1 - Cai-qiao Zhang
J0 - Journal of Zhejiang University Science B
VL - 19
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1700054


Abstract: 
A rapid decline in egg production of laying hens begins after 480 d of age. Such a rapid decrease results predominantly from the ovarian aging, accompanied by endocrine changes, decreased yolk synthesis and accumulation, and the reduction in follicles selected into the preovulatory hierarchy. In this study, hens at 90, 150, 280, and 580 d old (D90, D150, D280, and D580, respectively) were compared for yolk precursor formation in the liver to elucidate effects of aging on laying performance. The results showed that liver lipid synthesis increased remarkably in hens from D90 to D150, but decreased sharply at D580 as indicated by the changes in triglyceride (TG) levels. This result was consistent with the age-related changes of the laying performance. The levels of liver antioxidants and total antioxidant capacity decreased significantly in D580 hens and the methane dicarboxylic aldehyde in D580 hens was much higher than that at other stages. The serum 17β;-Estradiol level increased from D90 to D280, but decreased at D580 (P<0.05). The expression of estrogen receptor α and β mRNAs in the liver displayed similar changes to the serum 17β;-Estradiol in D580 hens. Expressions of the genes related to yolk precursor formation and enzymes responsible for fat acid synthesis were all decreased in D580 hens. These results indicated that decreased yolk precursor formation in the liver of the aged hens resulted from concomitant decreases of serum 17β;-Estradiol level, transcription levels of estrogen receptors and critical genes involved in yolk precursor synthesis, and liver antioxidant status.

不同产蛋阶段蛋鸡卵黄前体物质生成的变化研究

目的:比较不同日龄蛋鸡血清雌激素的水平、肝脏雌激素受体基因和卵黄前体物生成相关基因表达量、"肝脏-血液-卵巢轴"中甘油三酯和胆固醇的含量和肝脏抗氧化能力的动态变化,揭示蛋鸡卵黄前体物生成随着年龄增长的变化规律.
创新点:首次发现在蛋鸡衰老过程中雌激素作用衰退以及肝脏抗氧化能力降低致使肝脏中卵黄前体物合成下降,最终导致蛋鸡的产蛋性能下降.
方法:取90、150、280和580日龄蛋鸡各10只,检测血清中雌激素水平、肝脏雌激素受体基因表达水平、肝脏中卵黄前体物质合成和脂质代谢相关基因表达水平、"肝脏-血液-卵巢轴"中甘油三酯和胆固醇的含量及肝脏抗氧化能力,揭示蛋鸡卵黄前体物生成在衰老过程中的变化规律.
结论:在蛋鸡衰老过程中,血清雌激素水平、肝脏雌激素受体基因和卵黄前体物质合成相关基因表达量降低,肝脏抗氧化能力降低,引起肝脏合成甘油三酯的能力下降,最终导致卵黄前体物质合成能力降低.

关键词:脂质代谢;卵黄前体物质;雌激素;抗氧化物质;蛋鸡

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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