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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.12 P.981-986


Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Author(s):  LI Hui-chun, CHEN Qiao-zhen, MA Ying, ZHOU Jun-fu

Affiliation(s):  Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   zrjsk@zju.edu.cn

Key Words:  Schizophrenia, Nitric oxide (NO), Lipid peroxide (LPO), Glutathione peroxidase (GSH-Px), Catalase (CAT), Superoxide dismutase (SOD), Symptom

LI Hui-chun, CHEN Qiao-zhen, MA Ying, ZHOU Jun-fu. Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study[J]. Journal of Zhejiang University Science B, 2006, 7(12): 981-986.

@article{title="Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study",
author="LI Hui-chun, CHEN Qiao-zhen, MA Ying, ZHOU Jun-fu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study
%A LI Hui-chun
%A CHEN Qiao-zhen
%A MA Ying
%A ZHOU Jun-fu
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 12
%P 981-986
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0981

T1 - Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study
A1 - LI Hui-chun
A1 - CHEN Qiao-zhen
A1 - MA Ying
A1 - ZHOU Jun-fu
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 12
SP - 981
EP - 986
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0981

Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV) criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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