Similar articles

Abstract: Objective: To study the changes of oxidative metabolism and lipoperoxidative metabolism in patients with acnte viral myocarditis (AVM), and to research pathological chain reactions of a series of free radicals, and oxidative damage and lipoperoxidative damage in AVM patients' bodies. Methods: A random paired control design was used to investigate 70 cases of AVM patients and 70 cases of healthy adult volunteers (HAV) on the basis of contents of nitric oxide (NO), lipoperoxide (LPO) in plasma, and LPO in red blood cell (RBC) as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC as revealed by spectrophotometric assays. Results: Compared with the average values (AV) of the above biochemical parameters (BP) in the HAV group, the AV of NO in plasma, and LPO in plasma and in RBC in the AVM group were significantly increased (P=0.0001), while the AV of SOD, CAT and GSH-Px in the AVM group were significantly decreased (P=0.0001). Conclusion: The findings in this study suggested that in the AVM patients bodies the metabolism of NO was disturbed, and the pathological chain reactions of a series of free radicals were so severely aggravated, as to cause the oxidative damage and lipoperoxidative damage in the AVM patients' bodies.

[1] Dec,G. M., Palacios, I., Yasuda, T. et al., 1990. Antimyosin antibody cardiac imaging: its role in the diagnosis of myocarditis. J Am Coll Cardiol. 16:97-104.

[2] Ginsberg, M. D., Fietrich, W. D., 1989. Cerebrovascular diseases. 1st ed. Raven Press, New York, p.348-374.

[3] Hiraoka,Y., Kishimoto, C., Kurokawa, M. et al., 1992. Effects of polyethylene glycol conjugated superoxide dismutase on coxsackievims B3 myocarditis in mice. Cardiovasc Res., 26:956-961.

[4] Hiraoka, Y., Kishimoto, C., Takada, H. et al., 1993.Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 myocarditis in mice. Cardiovasc Res, 27:957-961.

[5] Hiraoka, Y., Kishimoto, C., Takada, H. et al., 1995. Effects of granulocyte colony-stimulating factor upon coxsackievirus B3 myocarditis in mice. Eur Heart J, 16:1900-1906.

[6] Lang, T.A., Secic, M. 1997. How to report statistics in medicine. Philadelphia: Port City Press, p.65-80.

[7] Murray, R.K. 2000. Muscle and the cytoskeleton. In: Murray, R. K., Granner, D. K., Mayes, P. A. et al.,ed. Harper's Biochemistry. 25th ed, McGraw-HillPress, New York, p.715-736.

[8] O'Connell, J. B., Reulund, D. G., 1998. Myocarditis and specific cardiomyopathies. In: Hurst's the heart. Alexander R. W., Schlant, R. C., O'Rourke V. F.R. A. et al., ed. 9th ed, McGraw-Hill Press, New York, p.2089-2107.

[9] Peters, N. S., Poole-Wilson, P. A., 1991a. Myocarditiscontinuing clinical and pathologic confusion. Am Heart J., 121:942-949.

[10] Peters, N.S., Poole-Wilson, P.A., 1991b. Myocarditis—a controversial disease. J. R. Soc Med., 84:1-9.

[11] Suzuki,H., Matsumori,A., Matoba,Y. et al., 1993. Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury. J Clin Invest.91:2727-2733.

[12] Wynne, J., Braunwald, E., 1997. The cardiomyopathies and myocarditis. In: Heart disease-A textbook of cardiovascular medicine, Braunwald, E. ed., 5th ed., Hacourt Asia Pte, Ltd, Singapore, p.1404-1463.

[13] Yang, Y. Z., 1995. The reference criterion of diagnosis about adult acute viral myocarditis. J. Clin Cardiol.,11:325-326 (in Chinese).

[14] Zhou, J. F., Yan, X. F., Guo, F. Z. et al., 2000a. Effects of cigarette smoking and smoking cessation on plasma constituents and enzyme activities related to oxidative stress. Biomed Environ Sci., 13:44-55.

[15] Zhou, J. F., Cai, D., Zhu, Y. G. et al., 2000b. A study on relationship of nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic cholecystitis. World J. Gastroenterology, 6:501-507.