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Journal of Zhejiang University SCIENCE A 2001 Vol.2 No.4 P.448~452

http://doi.org/10.1631/jzus.2001.0448


CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS


Author(s):  CHEN Peng, ZHOU Jun-fu

Affiliation(s):  The Second Affiliated Hospital, College of Midicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   zhuojun88@sina.com

Key Words:  oxidation, lipoperoxidation, nyocarditis, metabolism


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CHEN Peng, ZHOU Jun-fu. CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS[J]. Journal of Zhejiang University Science A, 2001, 2(4): 448~452.

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%A CHEN Peng
%A ZHOU Jun-fu
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DOI - 10.1631/jzus.2001.0448


Abstract: 
Objective: To study the changes of oxidative metabolism and lipoperoxidative metabolism in patients with acnte viral myocarditis (AVM), and to research pathological chain reactions of a series of free radicals, and oxidative damage and lipoperoxidative damage in AVM patients' bodies. Methods: A random paired control design was used to investigate 70 cases of AVM patients and 70 cases of healthy adult volunteers (HAV) on the basis of contents of nitric oxide (NO), lipoperoxide (LPO) in plasma, and LPO in red blood cell (RBC) as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC as revealed by spectrophotometric assays. Results: Compared with the average values (AV) of the above biochemical parameters (BP) in the HAV group, the AV of NO in plasma, and LPO in plasma and in RBC in the AVM group were significantly increased (P=0.0001), while the AV of SOD, CAT and GSH-Px in the AVM group were significantly decreased (P=0.0001). Conclusion: The findings in this study suggested that in the AVM patients bodies the metabolism of NO was disturbed, and the pathological chain reactions of a series of free radicals were so severely aggravated, as to cause the oxidative damage and lipoperoxidative damage in the AVM patients' bodies.

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