Full Text:   <1556>

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CLC number: Q752

On-line Access: 2019-10-09

Received: 2019-06-24

Revision Accepted: 2019-07-30

Crosschecked: 2019-09-12

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.920-927


Alternative role of noncoding RNAs: coding and noncoding properties

Author(s):  Gui-Zhen Zheng, Wei Li, Zhi-Yong Liu

Affiliation(s):  Department of Emergency Internal Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China; more

Corresponding email(s):   liuzy271@163.com

Key Words:  Non-coding RNA, Biological function, Micropeptides, Cellular stress

Gui-Zhen Zheng, Wei Li, Zhi-Yong Liu. Alternative role of noncoding RNAs: coding and noncoding properties[J]. Journal of Zhejiang University Science B, 2019, 20(11): 920-927.

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T1 - Alternative role of noncoding RNAs: coding and noncoding properties
A1 - Gui-Zhen Zheng
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J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900336

Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific “switch” triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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