JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.668-672

http://doi.org/10.1631/jzus.B2000133

Initial chest CT findings in COVID-19: correlation with clinical features

Author(s): Zhu-jing Shen, Nan Lu, Lu-lu Gao, Jian Lv, Hua-fu Luo, Ji-feng Jiang, Chao Xu, Shi-ya Li, Ju-jiang Mao, Kai Li, Xiao-pei Xu, Bin Lin
Affiliation(s): Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more
Corresponding email(s): zjdxlinbin@zju.edu.cn
Key Words: Coronavirus disease 2019 (COVID-19), Chest computed tomography (CT), Viral pneumonia, Lymphopenia

Share this article to： More <<< Previous Article \|

Abstract: In December 2019, coronavirus disease 2019 (COVID-19), a new de novo infectious disease, was first identified in Wuhan, China and quickly spread across China and around the world. The etiology was a novel betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). On Mar. 11, 2020, World Health Organization (WHO) characterized COVID-19 as a global pandemic. As of Mar. 22, 2020, over 292 000 confirmed COVID-19 cases have been reported globally. To date, COVID-19, with its high infectivity, has killed more people than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) combined (Wu and McGoogan, 2020).

2019冠状病毒病首次胸部CT影像表现及其与临床表现的相关性研究

目的:分析2019冠状病毒病(COVID-19)患者首次胸部CT影像表现及其与临床表现(包括发热症状、实验室检查)的相关性.
创新点:初步探索COVID-19肺部病灶与临床数据的相关性,对评估COVID-19患者提供一定的依据.
方法:纳入2020年1月16日至2020年2月6日入院的36例COVID-19患者,回顾性分析首次胸部CT的影像学表现,包括影像特征、分布模式、累及范围等,并进一步分析其与临床特征(包括发病时间、发热症状、白细胞计数等)的相关性.
结论:结果发现,在自然病程中,COVID-19肺部病变与发病时间显著相关,特别是发热症状.COVID-19病变范围与淋巴细胞计数呈负相关,淋巴细胞减少可能是COVID-19进展的标志之一.
关键词：2019冠状病毒病(COVID-19);胸部CT;发热;淋巴细胞减少

Reference

[1]Bernheim A, Mei XY, Huang MQ, et al., 2020. Chest CT findings in coronavirus disease-19 (COVID-19):relationship to duration of infection. Radiology, online.

[2]Chen NS, Zhou M, Dong X, et al., 2020. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 395(10223):507-513.

[3]Chung M, Bernheim A, Mei XY, et al., 2020. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology, 295(1):200230.

[4]Guan WJ, Ni ZY, Hu Y, et al., 2020. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med, 382(18):1708-1720.

[5]Huang CL, Wang YM, Li XW, et al., 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223):497-506.

[6]Lu RJ, Zhao X, Li J, et al., 2020. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 395(10224):565-574.

[7]Ooi CGC, Khong PL, Lam B, et al., 2003. Severe acute respiratory syndrome: relationship between radiologic and clinical parameters. Radiology, 229(2):492-499.

[8]Pan F, Ye TH, Sun P, et al., 2020. Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology, online.

[9]Pan YY, Guan HX, Zhou SC, et al., 2020. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV):a study of 63 patients in Wuhan, China. Eur Radiol, Online.

[10]Shi HS, Han XY, Jiang NC, et al., 2020. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet, 20(4):425-434.

[11]Song FX, Shi NN, Shan F, et al., 2020. Emerging 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology, 295(1):200274.

[12]Wang DW, Hu B, Hu C, et al., 2020. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA, 323(11):1061-1069.

[13]Wu J, Wu XJ, Zeng WB, et al., 2020. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol, 55(5):257-261.

[14]Wu ZY, McGoogan JM, 2020. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA, 323(13):1239-1242.

[15]Xu Z, Shi L, Wang YJ, et al., 2020. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med, 8(4):420-422.

[16]Yin YD, Wunderink RG, 2018. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology, 23(2):130-137.

[17]Zu ZY, Jiang MD, Xu PP, et al., 2020. Coronavirus disease 2019 (COVID-19):a perspective from China. Radiology, online.

[18]List of electronic supplementary materials

[19]Document S1 Supplementary materials

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Similar articles

- Go to

2019冠状病毒病首次胸部CT影像表现及其与临床表现的相关性研究

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference