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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2000483


Reduced GDCA levels are associated with negative clinical outcomes of gestational diabetes mellitus


Author(s):  Bo ZHU, Zhixin MA, Yuning ZHU, Lei FANG, Hong ZHANG, Hongwei KONG, Dajing XIA

Affiliation(s):  Women’ more

Corresponding email(s):   dxia@zju.edu.cn

Key Words:  Gestational diabetes mellitus, Bile acids, Insulin resistance, &beta, -cell compensation


Bo ZHU, Zhixin MA, Yuning ZHU, Lei FANG, Hong ZHANG, Hongwei KONG, Dajing XIA. Reduced GDCA levels are associated with negative clinical outcomes of gestational diabetes mellitus[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Bo ZHU, Zhixin MA, Yuning ZHU, Lei FANG, Hong ZHANG, Hongwei KONG, Dajing XIA",
journal="Journal of Zhejiang University Science B",
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year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000483"
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%T Reduced GDCA levels are associated with negative clinical outcomes of gestational diabetes mellitus
%A Bo ZHU
%A Zhixin MA
%A Yuning ZHU
%A Lei FANG
%A Hong ZHANG
%A Hongwei KONG
%A Dajing XIA
%J Journal of Zhejiang University SCIENCE B
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%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000483

TY - JOUR
T1 - Reduced GDCA levels are associated with negative clinical outcomes of gestational diabetes mellitus
A1 - Bo ZHU
A1 - Zhixin MA
A1 - Yuning ZHU
A1 - Lei FANG
A1 - Hong ZHANG
A1 - Hongwei KONG
A1 - Dajing XIA
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000483


Abstract: 
gestational diabetes mellitus (GDM) is characterized by glycemia and insulin disorders. bile acids (BAs) have emerged as vital signaling molecules in glucose metabolic regulation. BAs change in GDM are still unclear, it exerts great significance to illustrate the change of BAs in GDM. GDM patients and normal pregnant women were enrolled during the oral glucose tolerance test (OGTT) screening period. Fasting serums were sampled for the measurement of BAs. BAs metabolism profiles were analyzed both in pregnant women with GDM and those with normal glucose tolerance (NGT). Delivery characteristics, delivery gestational age, and infant birthweight were extracted from medical records. GDM patients presented distinctive features compared with NGT patients, including higher BMI, elevated serum glucose concentration, raised insulin (both fasting and OGTT), and increased HbA1c levels. Higher insulin resistance index (HOMA-IR) and decreased &beta;-cell compensation (DIo) were also prevalent in this group. Total bile acids (TBA) remained stable, but glycodeoxycholic acid (GDCA) and taurodeoxycholic acid (TDCA) levels declined significantly in GDM. GDCA was inversely correlated with HOMA-IR and positively correlated with DIo. No obvious differences in clinical outcome between the GDM and NGT groups were observed. However, GDM patients with high HOMA-IR and low DIo tended to have a higher cesarean delivery rate and younger delivery gestational age. GDCA provides a valuable biomarker to evaluate insulin resistance and DIo, and decreased GDCA levels predict poorer clinical outcomes for GDM.

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