CLC number:
On-line Access: 2021-03-12
Received: 2020-08-18
Revision Accepted: 2021-01-03
Crosschecked: 2021-02-22
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Bo ZHU, Zhixin MA, Yuning ZHU, Lei FANG, Hong ZHANG, Hongwei KONG, Dajing XIA. Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus[J]. Journal of Zhejiang University Science B, 2021, 22(3): 223-232.
@article{title="Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus",
author="Bo ZHU, Zhixin MA, Yuning ZHU, Lei FANG, Hong ZHANG, Hongwei KONG, Dajing XIA",
journal="Journal of Zhejiang University Science B",
volume="22",
number="3",
pages="223-232",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000483"
}
%0 Journal Article
%T Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus
%A Bo ZHU
%A Zhixin MA
%A Yuning ZHU
%A Lei FANG
%A Hong ZHANG
%A Hongwei KONG
%A Dajing XIA
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 3
%P 223-232
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000483
TY - JOUR
T1 - Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus
A1 - Bo ZHU
A1 - Zhixin MA
A1 - Yuning ZHU
A1 - Lei FANG
A1 - Hong ZHANG
A1 - Hongwei KONG
A1 - Dajing XIA
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 3
SP - 223
EP - 232
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000483
Abstract: gestational diabetes mellitus (GDM) is characterized by glycemia and insulin disorders. bile acids (BAs) have emerged as vital signaling molecules in glucose metabolic regulation. BA change in GDM is still unclear, which exerts great significance to illustrate the change of BAs in GDM. GDM patients and normal pregnant women were enrolled during the oral glucose tolerance test (OGTT) screening period. Fasting serums were sampled for the measurement of BAs. BA metabolism profiles were analyzed in both pregnant women with GDM and those with normal glucose tolerance (NGT). Delivery characteristics, delivery gestational age, and infant birthweight were extracted from medical records. GDM patients presented distinctive features compared with NGT patients, including higher body mass index (BMI), elevated serum glucose concentration, raised insulin (both fasting and OGTT), and increased hemoglobin A1c (HbA1c) levels. Higher homeostasis model assessment of insulin resistance (HOMA-IR) and decreased β-Cell compensation (i.e., oral disposition index (DIo)) were also prevalent in this group. Total BAs (TBAs) remained stable, but glycodeoxycholic acid (GDCA) and taurodeoxycholic acid (TDCA) levels declined significantly in GDM. GDCA was inversely correlated with HOMA-IR and positively correlated with DIo. No obvious differences in clinical outcome between the GDM and NGT groups were observed. However, GDM patients with high HOMA-IR and low DIo tended to have a higher cesarean delivery rate and younger delivery gestational age. In conclusion, GDCA provides a valuable biomarker to evaluate HOMA-IR and DIo, and decreased GDCA levels predict poorer clinical outcomes for GDM.
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