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On-line Access: 2022-02-17
Received: 2021-05-14
Revision Accepted: 2021-10-15
Crosschecked: 0000-00-00
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Citations: Bibtex RefMan EndNote GB/T7714
Yingyi GENG, Xintong WU, Haipeng LIU, Dingchang ZHENG, Ling XIA. Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease[J]. Journal of Zhejiang University Science B, 2022, 23(2): 123-140.
@article{title="Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease",
author="Yingyi GENG, Xintong WU, Haipeng LIU, Dingchang ZHENG, Ling XIA",
journal="Journal of Zhejiang University Science B",
volume="23",
number="2",
pages="123-140",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100425"
}
%0 Journal Article
%T Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease
%A Yingyi GENG
%A Xintong WU
%A Haipeng LIU
%A Dingchang ZHENG
%A Ling XIA
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 2
%P 123-140
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100425
TY - JOUR
T1 - Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease
A1 - Yingyi GENG
A1 - Xintong WU
A1 - Haipeng LIU
A1 - Dingchang ZHENG
A1 - Ling XIA
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 2
SP - 123
EP - 140
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100425
Abstract: The dysfunction of coronary microcirculation is an important cause of coronary artery disease (CAD). The index of microcirculatory resistance (IMR) is a quantitative evaluation of coronary microcirculatory function, which provides a significant reference for the prediction, diagnosis, treatment, and prognosis of CAD. IMR also plays a key role in investigating the interaction between epicardial and microcirculatory dysfunctions, and is closely associated with coronary hemodynamic parameters such as flow rate, distal coronary pressure, and aortic pressure, which have been widely applied in computational studies of CAD. However, there is currently a lack of consensus across studies on the normal and pathological ranges of IMR. The relationships between IMR and coronary hemodynamic parameters have not been accurately quantified, which limits the application of IMR in computational CAD studies. In this paper, we discuss the research gaps between IMR and its potential applications in the computational simulation of CAD. computational simulation based on the combination of IMR and other hemodynamic parameters is a promising technology to improve the diagnosis and guide clinical trials of CAD.
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