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On-line Access: 2022-06-08

Received: 2021-12-28

Revision Accepted: 2022-02-14

Crosschecked: 2022-06-08

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Jingru GUO


Huanmin YANG


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.6 P.461-480


Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress

Author(s):  Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG

Affiliation(s):  College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China; more

Corresponding email(s):   guojingru@byau.edu.cn, yanghm@byau.edu.cn

Key Words:  Low temperature, Stress, Autophagy, Metabolic reprogramming, Histone

Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG. Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress[J]. Journal of Zhejiang University Science B, 2022, 23(6): 461-480.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress
%A Jingjing LU
%A Shoupeng FU
%A Jie DAI
%A Jianwen HU
%A Shize LI
%A Hong JI
%A Zhiquan WANG
%A Jiahong YU
%A Jiming BAO
%A Bin XU
%A Jingru GUO
%A Huanmin YANG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 6
%P 461-480
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2101091

T1 - Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress
A1 - Jingjing LU
A1 - Shoupeng FU
A1 - Jie DAI
A1 - Jianwen HU
A1 - Shize LI
A1 - Hong JI
A1 - Zhiquan WANG
A1 - Jiahong YU
A1 - Jiming BAO
A1 - Bin XU
A1 - Jingru GUO
A1 - Huanmin YANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 6
SP - 461
EP - 480
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2101091

The negative effects of low temperature can readily induce a variety of diseases. We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure. We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis. The discovery, by genome-wide RNA sequencing, of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process. In addition, changes in metabolism drive the differentiation of macrophages by affecting histone modifications. Finally, we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure. Collectively, metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice, and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress.


4阿尔伯塔大学农业、生命与环境科学学院,加拿大埃德蒙顿,Alberta T5J 4P6


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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