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CLC number: R589.2

On-line Access: 2016-06-03

Received: 2016-02-19

Revision Accepted: 2016-04-28

Crosschecked: 2016-05-12

Cited: 4

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Citations:  Bibtex RefMan EndNote GB/T7714


Wei Chen


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.6 P.437-446


Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice

Author(s):  Hong-ming Su, Li-na Feng, Xiao-dong Zheng, Wei Chen

Affiliation(s):  Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   zjuchenwei@zju.edu.cn

Key Words:  Myricetin, Obesity, Adipogenesis, Oxidative stress

Hong-ming Su, Li-na Feng, Xiao-dong Zheng, Wei Chen. Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice[J]. Journal of Zhejiang University Science B, 2016, 17(6): 437-446.

@article{title="Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice",
author="Hong-ming Su, Li-na Feng, Xiao-dong Zheng, Wei Chen",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice
%A Hong-ming Su
%A Li-na Feng
%A Xiao-dong Zheng
%A Wei Chen
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 6
%P 437-446
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600074

T1 - Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice
A1 - Hong-ming Su
A1 - Li-na Feng
A1 - Xiao-dong Zheng
A1 - Wei Chen
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 6
SP - 437
EP - 446
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600074

Background: myricetin is a naturally occurring antioxidant commonly found in various plants. However, little information is available with respect to its direct anti-obesity effects. Objective: This study was undertaken to investigate the effect of myricetin on high-fat diet (HFD)-induced obesity in C57BL/6 mice. Results: Administration of myricetin dramatically reduced the body weight of diet-induced obese mice compared with solely HFD-induced mice. Several parameters related to obesity including serum glucose, triglyceride, and cholesterol were significantly decreased in myricetin-treated mice. Moreover, obesity-associated oxidative stress (glutathione peroxidase (GPX) activity, total antioxidant capacity (T-AOC), and malondialdehyde (MDA)) and inflammation (tumor necrosis factor-α (TNF-α)) were ameliorated in myricetin-treated mice. Further investigation revealed that the protective effect of myricetin against HFD-induced obesity in mice appeared to be partially mediated through the down-regulation of mRNA expression of adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and lipogenic transcription factor sterol regulatory element-binding protein 1c (SREBP-1c). Conclusions: Consumption of myricetin may help to prevent obesity and obesity-related metabolic complications.


方法:将C57BL/6小鼠分为正常膳食组(ND,n=12)和高脂膳食组(HFD,n=24),分别给予正常膳食和高脂膳食喂食2周。之后,高脂膳食组分为高脂膳食组(n=12)和杨梅素保护组(HFD+M,灌胃150 mg/(kg·d)的杨梅素,n=12),继续处理10周。分析小鼠常规生理指标(体重和脏器重量)、生化指标(血糖浓度、甘油三酯和总胆固醇含量)、氧化应激指标(谷胱甘肽过氧化物酶(GPX)、超氧化物歧化酶(SOD)和总抗氧化能力(T-AOC))和炎症指标(肿瘤坏死因子α(TNF-α))等。苏木精-伊红染色法(H&E)和油红染色法分别观察脂肪组织和肝脏组织形态。实时逆转录聚合酶链反应(RT-PCR)分析小鼠脂肪组织PPARγC/EBPαSREBP-1c等基因的mRNA表达水平。


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