CLC number: R589.2
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2016-05-12
Cited: 4
Clicked: 5675
Hong-ming Su, Li-na Feng, Xiao-dong Zheng, Wei Chen. Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice[J]. Journal of Zhejiang University Science B, 2016, 17(6): 437-446.
@article{title="Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice",
author="Hong-ming Su, Li-na Feng, Xiao-dong Zheng, Wei Chen",
journal="Journal of Zhejiang University Science B",
volume="17",
number="6",
pages="437-446",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600074"
}
%0 Journal Article
%T Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice
%A Hong-ming Su
%A Li-na Feng
%A Xiao-dong Zheng
%A Wei Chen
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 6
%P 437-446
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600074
TY - JOUR
T1 - Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice
A1 - Hong-ming Su
A1 - Li-na Feng
A1 - Xiao-dong Zheng
A1 - Wei Chen
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 6
SP - 437
EP - 446
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600074
Abstract: Background: myricetin is a naturally occurring antioxidant commonly found in various plants. However, little information is available with respect to its direct anti-obesity effects. Objective: This study was undertaken to investigate the effect of myricetin on high-fat diet (HFD)-induced obesity in C57BL/6 mice. Results: Administration of myricetin dramatically reduced the body weight of diet-induced obese mice compared with solely HFD-induced mice. Several parameters related to obesity including serum glucose, triglyceride, and cholesterol were significantly decreased in myricetin-treated mice. Moreover, obesity-associated oxidative stress (glutathione peroxidase (GPX) activity, total antioxidant capacity (T-AOC), and malondialdehyde (MDA)) and inflammation (tumor necrosis factor-α (TNF-α)) were ameliorated in myricetin-treated mice. Further investigation revealed that the protective effect of myricetin against HFD-induced obesity in mice appeared to be partially mediated through the down-regulation of mRNA expression of adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and lipogenic transcription factor sterol regulatory element-binding protein 1c (SREBP-1c). Conclusions: Consumption of myricetin may help to prevent obesity and obesity-related metabolic complications.
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