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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.10 P.812-822


Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes

Author(s):  Jing CHEN, Jian CHEN, Lie WANG

Affiliation(s):  Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   wanglie@zju.edu.cn, zrchenjian@zju.edu.cn

Key Words:  Tertiary lymphoid structure (TLS), Tumor-infiltrating immunocyte, Tumor microenvironment (TME)

Jing CHEN, Jian CHEN, Lie WANG. Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes[J]. Journal of Zhejiang University Science B, 2022, 23(10): 812-822.

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%T Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
%A Jing CHEN
%A Jian CHEN
%J Journal of Zhejiang University SCIENCE B
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%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200174

T1 - Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
A1 - Jing CHEN
A1 - Jian CHEN
A1 - Lie WANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 10
SP - 812
EP - 822
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200174

Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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