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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.1 P.12-28

http://doi.org/10.1631/jzus.B1900452


MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages


Author(s):  Chong Chen, Jia-Ming Liu, Yun-Ping Luo

Affiliation(s):  Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; more

Corresponding email(s):   ypluo@ibms.pumc.edu.cn

Key Words:  MicroRNA, Tumor microenvironment, Tumor-associated macrophage, Functional polarization


Chong Chen, Jia-Ming Liu, Yun-Ping Luo. MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages[J]. Journal of Zhejiang University Science B, 2020, 21(1): 12-28.

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journal="Journal of Zhejiang University Science B",
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pages="12-28",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900452"
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DOI - 10.1631/jzus.B1900452


Abstract: 
tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME) and are critical for cancer initiation and progression. microRNAs (miRNAs) could notably influence the phenotype of TAMs through various targets and signal pathways during cancer progression due to their post-transcriptional regulation. In this review, we discuss mainly the regulatory function of miRNAs on macrophage differentiation, functional polarization, and cellular crosstalk. Firstly, during the generation process, miRNAs take part in the differentiation from myeloid cells to mature macrophages, and this maturation process directly influences their recruitment into the TME, attracted by tumor cells. Secondly, macrophages in the TME can be either tumor-promoting or tumor-suppressing, depending on their functional polarization. Large numbers of miRNAs can influence the polarization of macrophages, which is crucial for tumor progression, including tumor cell invasion, intravasation, extravasation, and premetastatic site formation. Thirdly, crosstalk between tumor cells and macrophages is essential for TME formation and tumor progression, and miRNAs can be the mediator of communication in different forms, especially when encapsulated in microvesicles or exosomes. We also assess the potential value of certain macrophage-related miRNAs (MRMs) as diagnostic and prognostic markers, and discuss the possible development of MRM-based therapies.

MicroRNA在肿瘤免疫中的作用:对肿瘤相关巨噬细胞的功能调控

概要:肿瘤相关巨噬细胞(TAM)是肿瘤微环境中比例最高的免疫细胞,对肿瘤的发生和发展起着重要的作用.在肿瘤的进展过程中,microRNA可以通过转录后调控的方式作用于多种靶点与信号通路来影响TAM的表型.本文主要讨论了microRNA对巨噬细胞分化、功能性极化和细胞间信息交流的调控作用.首先,microRNA参与了从髓样细胞向成熟巨噬细胞的分化过程,这一过程直接影响了肿瘤微环境中肿瘤细胞对巨噬细胞的招募.其次,microRNA参与了TAM的功能极化,使之表现为促癌或抑癌表型,影响了肿瘤的生长和转移.第三,肿瘤细胞与巨噬细胞间的相互作用对肿瘤微环境的形成和肿瘤的进展而言是必要的,microRNA可以通过胞外颗粒的形式作为交流的媒介.此外,本文还讨论了巨噬细胞相关microRNA作为肿瘤诊断和预后标志物的潜在价值,以及基于巨噬细胞相关microRNA的肿瘤治疗新策略的应用前景.
关键词:MicroRNA;肿瘤微环境;肿瘤相关巨噬细胞;功能性极化

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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