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On-line Access: 2023-05-15
Received: 2022-09-25
Revision Accepted: 2023-02-02
Crosschecked: 2023-05-16
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CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest
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Wen CAO, Shunnan YAO, Anqi LI, Haoguang CHEN, Enfan ZHANG, Liqin CAO, Jinna ZHANG, Yifan HOU, Zhenfeng DAI, Jing CHEN, Xi HUANG, Li YANG, Zhen CAI. CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest[J]. Journal of Zhejiang University Science B, 2023, 24(5): 442-454.
@article{title="CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest",
author="Wen CAO, Shunnan YAO, Anqi LI, Haoguang CHEN, Enfan ZHANG, Liqin CAO, Jinna ZHANG, Yifan HOU, Zhenfeng DAI, Jing CHEN, Xi HUANG, Li YANG, Zhen CAI",
journal="Journal of Zhejiang University Science B",
volume="24",
number="5",
pages="442-454",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200465"
}
%0 Journal Article
%T CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest
%A Wen CAO
%A Shunnan YAO
%A Anqi LI
%A Haoguang CHEN
%A Enfan ZHANG
%A Liqin CAO
%A Jinna ZHANG
%A Yifan HOU
%A Zhenfeng DAI
%A Jing CHEN
%A Xi HUANG
%A Li YANG
%A Zhen CAI
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 5
%P 442-454
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200465
TY - JOUR
T1 - CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest
A1 - Wen CAO
A1 - Shunnan YAO
A1 - Anqi LI
A1 - Haoguang CHEN
A1 - Enfan ZHANG
A1 - Liqin CAO
A1 - Jinna ZHANG
A1 - Yifan HOU
A1 - Zhenfeng DAI
A1 - Jing CHEN
A1 - Xi HUANG
A1 - Li YANG
A1 - Zhen CAI
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 5
SP - 442
EP - 454
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200465
Abstract: CUDC-101, an effective and multi-target inhibitor of epidermal growth factor receptor (EGFR), histone deacetylase (HDAC), and human epidermal growth factor receptor 2 (HER2), has been reported to inhibit many kinds of cancers, such as acute promyelocytic leukemia and non-Hodgkin’s lymphoma. However, no studies have yet investigated whether CUDC-101 is effective against myeloma. Herein, we proved that CUDC-101 effectively inhibits the proliferation of multiple myeloma (MM) cell lines and induces cell apoptosis in a time- and dose-dependent manner. Moreover, CUDC-101 markedly blocked the signaling pathway of EGFR/phosphoinositide-3-kinase (PI3K) and HDAC, and regulated the cell cycle G2/M arrest. Moreover, we revealed through in vivo experiment that CUDC-101 is a potent anti-myeloma drug. bortezomib is one of the important drugs in MM treatment, and we investigated whether CUDC-101 has a synergistic or additive effect with bortezomib. The results showed that this drug combination had a synergistic anti-myeloma effect by inducing G2/M phase blockade. Collectively, our findings revealed that CUDC-101 could act on its own or in conjunction with bortezomib, which provides insights into exploring new strategies for MM treatment.
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