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Qianming CHEN

https://orcid.org/0000-0002-5371-4432

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.10 P.853-867

http://doi.org/10.1631/jzus.B2200702


Current status and future prospects of stomatology research


Author(s):  Qianming CHEN, Yahui WANG, Jing SHUAI

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   qmchen@zju.edu.cn

Key Words:  Stomatology, Dental medicine, Systemic disease, Material, Innovative technique


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Qianming CHEN, Yahui WANG, Jing SHUAI. Current status and future prospects of stomatology research[J]. Journal of Zhejiang University Science B, 2023, 24(10): 853-867.

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Abstract: 
Research in stomatology (dental medicine) continues to expand globally and is oriented towards solving clinical issues, focusing on clarifying the clinical relevance and potential mechanisms of oral‍–‍systemic connections via clinical epidemiology, oral microecological characterization, and the establishment of animal models. Interdisciplinary integration of materials science and tissue engineering with stomatology is expected to lead to the creation of innovative materials and technologies to better resolve the most prevalent and challenging clinical issues such as peri-implantitis, soft and hard tissue defects, and dentin hypersensitivity. With the rapid development of artificial intelligence (AI), 5th generation mobile communication technology (5G), and big data applications, “intelligent stomatology” is emerging to build models for better clinical diagnosis and management, accelerate the reform of education, and support the growth and advancement of scientific research. Here, we summarized the current research status, and listed the future prospects and limitations of these three aspects, aiming to provide a basis for more accurate etiological exploration, novel treatment methods, and abundant big data analysis in stomatology to promote the translation of research achievements into practical applications for both clinicians and the public.

口腔医学研究现状与展望

陈谦明,王雅慧,帅旌
浙江大学医学院附属口腔医院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学重点实验室,浙江大学肿瘤研究中心,中国杭州市,310006
摘要:随着口腔医学研究在全球范围内不断扩展,口腔医学现以解决临床问题为导向,重点通过临床流行病学、口腔微生态表征和动物模型的建立来阐明口腔与系统性疾病的临床相关性和潜在机制。材料科学及组织工程与口腔医学的跨学科整合有望通过推动创新材料发展和技术研发,更好地解决如种植体周围炎、软硬组织缺损和牙本质过敏等目前最普遍、最具挑战性的临床问题。随着人工智能、5G和大数据等应用技术的快速发展,"智能口腔"正在兴起,以便搭建更好的临床诊断和管理模式,加快教育改革,推动科研发展。基于此,本文综述了口腔医学目前的研究现状,并列举了上述3个方面未来的发展前景和局限性,旨在为口腔医学更准确的病因探索、新颖的治疗方法建立和丰富的大数据分析提供依据,从而促进研究成果向服务于临床医生和民众的实际应用转化。

关键词:口腔医学;牙医学;系统性疾病;材料;新型技术

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AbbassyMA, WatariI, BakryAS, et al., 2015. Diabetes detrimental effects on enamel and dentine formation. J Dent, 43(5):589-596.

[2]AhadA, TahirM, Aman SheikhM, et al., 2020. Technologies trend towards 5G network for smart health-care using IoT: a review. Sensors (Basel), 20(14):4047.

[3]AngstPDM, DutraDAM, MansoIS, et al., 2020. Association between oral health-related quality of life and periodontal status in patients with leukemia. Int Dent J, 70(5):‍381-387.

[4]AranyPR, 2016. Craniofacial wound healing with photobiomodulation therapy: new insights and current challenges. J Dent Res, 95(9):977-984.

[5]BarakS, Oettinger-BarakO, MachteiEE, et al., 2007. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol, 78(4):670-676.

[6]BastosMF, BrilhanteFV, GonçalvesTED, et al., 2010. Hypertension may affect tooth-supporting alveolar bone quality: a study in rats. J Periodontol, 81(7):1075-1083.

[7]Belda-FerreP, AlcarazLD, Cabrera-RubioR, et al., 2012. The oral metagenome in health and disease. ISME J, 6(1):‍46-56.

[8]BinghamCO III, MoniM, 2013. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol, 25(3):345-353.

[9]CasamassimoPS, FlaitzCM, HammersmithK, et al., 2018. Recognizing the relationship between disorders in the oral cavity and systemic disease. Pediatr Clin North Am, 65(5):1007-1032.

[10]CasarinRCV, BarbagalloA, MeulmanT, et al., 2013. Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J Periodontal Res, 48(1):30-36.

[11]Castro-RaucciLMS, FrancischiniMS, TeixeiraLN, et al., 2016. Titanium with nanotopography induces osteoblast differentiation by regulating endogenous bone morphogenetic protein expression and signaling pathway. J Cell Biochem, 117(7):1718-1726.

[12]ChengK, SunY, WanHP, et al., 2015. Improved light-induced cell detachment on rutile TiO2 nanodot films. Acta Biomater, 26:347-354.

[13]ChengK, WangTT, YuML, et al., 2016. Effects of RGD immobilization on light-induced cell sheet detachment from TiO2 nanodots films. Mater Sci Eng C Mater Biol Appl, 63:240-246.

[14]CostalongaM, HerzbergMC, 2014. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett, 162(2):22-38.

[15]de Medeiros Vanderlei JMTM, MessoraMR, FernandesPG, et al., 2013. Arterial hypertension perpetuates alveolar bone loss. Clin Exp Hypertens, 35(1):1-5.

[16]Díaz-ZúñigaJ, MoreJ, Melgar-RodríguezS, et al., 2020. Alzheimer’s disease-like pathology triggered by Porphyromonas gingivalis in wild type rats is serotype dependent. Front Immunol, 11:588036.

[17]EliasGP, dos SantosOAM, SassakiKT, et al., 2006. Dental mineralization and salivary activity are reduced in offspring of spontaneously hypertensive rats (SHR). J Appl Oral Sci, 14(4):253-259.

[18]FanXZ, AlekseyenkoAV, WuJ, et al., 2018. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut, 67(1):120-127.

[19]GaoL, XuTS, HuangG, et al., 2018. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell, 9(5):488-500.

[20]Guillaume-GentilO, GabiM, Zenobi-WongM, et al., 2011a. Electrochemically switchable platform for the micro-patterning and release of heterotypic cell sheets. Biomed Microdevices, 13(1):221-230.

[21]Guillaume-GentilO, SemenovOV, ZischAH, et al., 2011b. pH-controlled recovery of placenta-derived mesenchymal stem cell sheets. Biomaterials, 32(19):4376-4384.

[22]GuptaR, SrivastavaD, SahuM, et al., 2021. Artificial intelligence to deep learning: machine intelligence approach for drug discovery. Mol Divers, 25(3):1315-1360.

[23]HaraszthyVI, ZambonJJ, TrevisanM, et al., 2000. Identification of periodontal pathogens in atheromatous plaques. J Periodontol, 71(10):1554-1560.

[24]HenchLL, ThompsonI, 2010. Twenty-first century challenges for biomaterials. J R Soc Interface, 7(S4):S379-S391.

[25]HijaziK, LoweT, MehargC, et al., 2015. Mucosal microbiome in patients with recurrent aphthous stomatitis. J Dent Res, 94(S3):87S-94S.

[26]HongY, YuMF, WengWJ, et al., 2013. Light-induced cell detachment for cell sheet technology. Biomaterials, 34(1):11-18.

[27]HotchkissKM, ReddyGB, HyzySL, et al., 2016. Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomater, 31:‍425-434.

[28]HungCC, ChayaA, LiuK, et al., 2019. The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway. Acta Biomater, 98:246-255.

[29]JingJG, ChenSS, LuQH, 2019. Gradient photothermal field for precisely directing cell sheet detachment. Adv Biosyst, 3(5):e1800334.

[30]KamerAR, CraigRG, PirragliaE, et al., 2009. TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer’s disease patients and normal subjects. J Neuroimmunol, 216(1-2):92-97.

[31]KilianM, 2018. The oral microbiome ‍– ‍friend or foe? Eur J Oral Sci, 126(S1):5-12.

[32]KorenO, SporA, FelinJ, et al., 2011. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci USA, 108(S1):4592-4598.

[33]KrishnanK, ChenT, PasterBJ, 2017. A practical guide to the oral microbiome and its relation to health and disease. Oral Dis, 23(3):276-286.

[34]KwonHB, ParkYS, HanJS, 2018. Augmented reality in dentistry: a current perspective. Acta Odontol Scand, 76(7):497-503.

[35]LeiteCLA, RedinsCA, VasquezEC, et al., 2005. Experimental-induced periodontitis is exacerbated in spontaneously hypertensive rats. Clin Exp Hypertens, 27(6):523-531.

[36]LeónR, SilvaN, OvalleA, et al., 2007. Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol, 78(7):1249-1255.

[37]LiJPO, LiuHR, TingDSJ, et al., 2021. Digital technology, tele-medicine and artificial intelligence in ophthalmology: a global perspective. Prog Retin Eye Res, 82:100900.

[38]LiY, WangK, ZhangB, et al., 2019. Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus. Int J Oral Sci, 11(2):13.

[39]LinDJ, YangLS, WenLL, et al., 2021. Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis. Mucosal Immunol, 14(6):1247-1258.

[40]MagerDL, HaffajeeAD, DevlinPM, et al., 2005. The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects. J Transl Med, 3:27.

[41]MarrugantiC, DiscepoliN, GaetaC, et al., 2021. Dental caries occurrence in inflammatory bowel disease patients: a systematic review and meta-analysis. Caries Res, 55(5):485-495.

[42]MastersK, 2019. Artificial intelligence in medical education. Med Teach, 41(9):976-980.

[43]MatshaTE, PrinceY, DavidsS, et al., 2020. Oral microbiome signatures in diabetes mellitus and periodontal disease. J Dent Res, 99(6):658-665.

[44]MatsumotoS, OkabeY, SetoyamaH, et al., 1998. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain. Gut, 43(1):71-78.

[45]MohanA, WaraUU, ShaikhMTA, et al., 2021. Telesurgery and robotics: an improved and efficient era. Cureus, 13(3):e14124.

[46]NaJ, SongSY, KimJD, et al., 2018. Protein-engineered large area adipose-derived stem cell sheets for wound healing. Sci Rep, 8:15869.

[47]ParkJC, SuCX, JungIH, et al., 2011. Mechanism of alveolar bone loss in a collagen-induced arthritis model in mice. J Clin Periodontol, 38(2):122-130.

[48]PasterBJ, OlsenI, AasJA, et al., 2006. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000, 42:80-87.

[49]PietropaoliD, del PintoR, CorridoniD, et al., 2014. Occurrence of spontaneous periodontal disease in the SAMP1/YitFc murine model of Crohn disease. J Periodontol, 85(12):1799-1805.

[50]PoytonRO, BallKA, 2011. Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med, 11(57):154-159.

[51]QianXS, ZhangS, DuanL, et al., 2021. Periodontitis deterior

[52]ates cognitive function and impairs neurons and glia in a mouse model of Alzheimer’s disease. J Alzheimers Dis, 79(4):1785-1800.

[53]RamamurthyNS, GreenwaldRA, CelikerMY, et al., 2005. Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol, 76(2):229-233.

[54]RefaiAK, TextorM, BrunetteDM, et al., 2004. Effect of titanium surface topography on macrophage activation and secretion of proinflammatory cytokines and chemokines. J Biomed Mater Res A, 70(2):194-205.

[55]RiviereGR, RiviereKH, SmithKS, 2002. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer’s disease. Oral Microbiol Immunol, 17(2):113-118.

[56]RoglerG, SinghA, KavanaughA, et al., 2021. Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management. Gastroenterology, 161(4):1118-1132.

[57]SaghiriMA, KaramifarK, FakharzadehA, et al., 2020. Effect of diabetes on tubular density and push-out bond strength of mineral trioxide aggregate to dentin. J Endod, 46(11):1584-1591.

[58]SaghiriMA, SheibaniN, KawaiT, et al., 2022. Diabetes negatively affects tooth enamel and dentine microhardness: an in-vivo study. Arch Oral Biol, 139:105434.

[59]SaidHS, SudaW, NakagomeS, et al., 2014. Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res, 21(1):15-25.

[60]SanoT, MatsuuraT, OzakiK, et al., 2011. Dental caries and caries-related periodontitis in type 2 diabetic mice. Vet Pathol, 48(2):506-512.

[61]ScherJU, UbedaC, EquindaM, et al., 2012. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum, 64(10):3083-3094.

[62]SchwendickeF, SinghT, LeeJH, et al., 2021. Artificial intelligence in dental research: checklist for authors, reviewers, readers. J Dent, 107:103610.

[63]ShanT, TayFR, GuL, 2021. Application of artificial intelligence in dentistry. J Dent Res, 100(3):232-244.

[64]ShangJJ, YangQB, ZhaoHY, et al., 2013. Preliminary molecu

[65]lar analysis of bacterial composition in periapical lesions with primary endodontic infections of deciduous teeth. Chin Med J (Engl), 126(16):3112-3117.

[66]ShenX, ShenX, LiB, et al., 2021. Abnormal macrophage polarization impedes the healing of diabetes-associated tooth sockets. Bone, 143:115618.

[67]ShiY, ShenDN, ZhengHY, et al., 2019. Therapeutic management of demineralized dentin surfaces using a mineralizing adhesive to seal and mineralize dentin, dentinal tubules, and odontoblast processes. ACS Biomater Sci Eng, 5(10):5481-5488.

[68]SpliethCH, TachouA, 2013. Epidemiology of dentin hypersensitivity. Clin Oral Investig, 17(S1):3-8.

[69]SrinivasanK, ViswanadB, AsratL, et al., 2005. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res, 52(4):313-320.

[70]TaniguchiN, FujibayashiS, TakemotoM, et al., 2016. Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: an in vivo experiment. Mater Sci Eng C Mater Biol Appl, 59:690-701.

[71]TsukasakiM, TakayanagiH, 2019. Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol, 19(10):626-642.

[72]TurnbaughPJ, LeyRE, HamadyM, et al., 2007. The human microbiome project. Nature, 449(7164):804-810.

[73]UchiboriS, SekiyaT, SatoT, et al., 2020. Suppression of tooth movement-induced sclerostin expression using β-adrenergic receptor blockers. Oral Dis, 26(3):621-629.

[74]WangHR, XiaoZH, YangJ, et al., 2017. Oriented and ordered biomimetic remineralization of the surface of demineralized dental enamel using HAP@ACP nanoparticles guided by glycine. Sci Rep, 7:40701.

[75]WangXJ, XuSQ, ZhouSW, et al., 2016. Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review. Biomaterials, 83:127-141.

[76]WangY, JiangZW, YuK, et al., 2017. Improved osseointegrating functionality of cell sheets on anatase TiO2 nanoparticle surfaces. RSC Adv, 7(57):35845-35853.

[77]WuZF, WangXK, WangZ, et al., 2017. Self-etch adhesive as a carrier for ACP nanoprecursors to deliver biomimetic remineralization. ACS Appl Mater Interfaces, 9(21):17710-17717.

[78]XiaoE, MattosM, VieiraGHA, et al., 2017. Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host Microbe, 22(1):‍‍120-128.e4.

[79]YanXM, YangMX, LiuJ, et al., 2015. Discovery and validation of potential bacterial biomarkers for lung cancer. Am J Cancer Res, 5(10):3111-3122.

[80]YangYH, CaiQY, ShuXO, et al., 2019. Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer, 144(10):2381-2389.

[81]YuDM, GuoS, YuM, et al., 2022. Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content. Bioact Mater, 10:323-334.

[82]ZaidH, Ismael-ShanakS, MichaeliA, et al., 2012. Computerized modeling techniques predict the 3D structure of H4R: facts and fiction. Front Biosci (Landmark Ed), 17(1):232-247.

[83]ZhangX, ZhangDY, JiaHJ, et al., 2015. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med, 21(8):895-905.

[84]ZhangYH, WangX, LiHX, et al., 2018. Human oral microbiota and its modulation for oral health. Biomed Pharmacother, 99:883-893.

[85]ZhongFS, XingJ, LiXT, et al., 2018. Artificial intelligence in drug design. Sci China Life Sci, 61(10):1191-1204.

[86]ZhuXH, ShaoLZ, LiuZY, et al., 2023. MRI-derived radiomics models for evaluation of diagnosis, aggressiveness, and prognosis in prostate cancer. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(8):‍663-681.

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