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CLC number: R575

On-line Access: 2016-11-03

Received: 2016-03-03

Revision Accepted: 2016-05-14

Crosschecked: 2016-10-10

Cited: 6

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yang Guo

http://orcid.org/0000-0002-2125-0637

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.11 P.831-841

10.1631/jzus.B1600101


Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis


Author(s):  Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   mavis199005@zju.edu.cn, cxiang@zju.edu.cn

Key Words:  Liver fibrosis, Cell therapy, Mesenchymal stem cells


Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang. Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis[J]. Journal of Zhejiang University Science B, 2016, 17(11): 831-841.

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publisher="Zhejiang University Press & Springer",
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A1 - Yang Guo
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DOI - 10.1631/jzus.B1600101


Abstract: 
liver fibrosis is the end-stage of many chronic liver diseases and is a significant health threat. The only effective therapy is liver transplantation, which still has many problems, including the lack of donor sources, immunological rejection, and high surgery costs, among others. However, the use of cell therapy is becoming more prevalent, and mesenchymal stem cells (MSCs) seem to be a promising cell type for the treatment of liver fibrosis. MSCs have multiple differentiation abilities, allowing them to migrate directly into injured tissue and differentiate into hepatocyte-like cells. Additionally, MSCs can release various growth factors and cytokines to increase hepatocyte regeneration, regress liver fibrosis, and regulate inflammation and immune responses. In this review, we summarize the current uses of MSC therapies for liver fibrosis and suggest potential future applications.

间充质干细胞治疗肝纤维化的现况和前景

概要:许多慢性肝病发展到终末阶段形成肝纤维化进而转变成肝硬化,严重威胁人们的健康。目前临床治疗肝纤维化的有效方法是肝移植,但由于供体缺乏、免疫排斥和治疗费用昂贵等诸多缺陷,这种疗法并不是一种理想的治疗途径。近些年细胞治疗研究火热,间充质干细胞作为一种来源广泛、可定向迁移和多向分化的治疗载体,在肝纤维化治疗上具有广阔的应用前景。本文对间充质干细胞治疗肝纤维化的现状进行归纳,并对其可行性、局限性及应用前景进行分析。
关键词:间充质干细胞;肝纤维化;细胞治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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