Full Text:   <572>

Summary:  <231>

CLC number: 

On-line Access: 2023-11-14

Received: 2023-04-10

Revision Accepted: 2023-06-18

Crosschecked: 2023-11-15

Cited: 0

Clicked: 603

Citations:  Bibtex RefMan EndNote GB/T7714


Liwen WANG


Lanfang LI


-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.1053-1056


HPCAL1 is a novel driver of autophagy-dependent ferroptosis

Author(s):  Liwen WANG, Li Qin, Huimei LIU, Lanfang LI

Affiliation(s):  Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China; more

Corresponding email(s):   llanfang6@126.com

Key Words:  Autophagy, Ferroptosis, Lipid peroxidation, HPCAL1, CDH2

Liwen WANG, Li Qin, Huimei LIU, Lanfang LI. HPCAL1 is a novel driver of autophagy-dependent ferroptosis[J]. Journal of Zhejiang University Science B, 2023, 24(11): 1053-1056.

@article{title="HPCAL1 is a novel driver of autophagy-dependent ferroptosis",
author="Liwen WANG, Li Qin, Huimei LIU, Lanfang LI",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T HPCAL1 is a novel driver of autophagy-dependent ferroptosis
%A Liwen WANG
%A Li Qin
%A Huimei LIU
%A Lanfang LI
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 11
%P 1053-1056
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300241

T1 - HPCAL1 is a novel driver of autophagy-dependent ferroptosis
A1 - Liwen WANG
A1 - Li Qin
A1 - Huimei LIU
A1 - Lanfang LI
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 11
SP - 1053
EP - 1056
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300241

autophagy is a highly conserved physiological process in cells that degrades excess or damaged organelles, large protein aggregates, and pathogens via the lysosomal system (Li et al., 2021). autophagy generally increases the self-protection mechanism of cells, which plays an important role in the maintenance of cell homeostasis as well as the synthesis, degradation, and recycling of cell products. However, in certain circumstances, activation of autophagy or excessive autophagy can lead to cell death, a phenomenon called autophagy-dependent cell death (Liu et al., 2020). Recent research has found that, under certain conditions, autophagy activation or excessive autophagy can regulate ferroptosis through corresponding mechanisms (Xie et al., 2023).


王丽雯1, 李琴1, 刘惠美2, 李兰芳1


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]BaiYS, MengLJ, HanL, et al., 2019. Lipid storage and lipophagy regulates ferroptosis. Biochem Biophys Res Commun, 508(4):997-1003.

[2]BaoZ, HuaL, YeY, et al., 2021. MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma. Neuro Oncol, 23:‍2014-2027. http://dx.doi.org/10.1093/neuonc/noab114

[3]ChenX, KangR, KroemerG, et al., 2021. Ferroptosis in infection, inflammation, and immunity. J Exp Med, 218(6):e20210518.

[4]ChenX, SongXX, LiJB, et al., 2023. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis. Autophagy, 19(1):54-74.

[5]HouW, XieYC, SongXX, et al., 2016. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy, 12(8):1425-1428.

[6]LiW, HePC, HuangYG, et al., 2021. Selective autophagy of intracellular organelles: recent research advances. Theranostics, 11(1):222-256.

[7]LiuJ, KuangFM, KroemerG, et al., 2020. Autophagy-dependent ferroptosis: machinery and regulation. Cell Chem Biol, 27(4):420-435.

[8]QinX, ZhangJ, WangB, et al., 2021. Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy, 17(12):‍4266-4285.

[9]RuQ, LiYS, XieWQ, et al., 2023. Fighting age-related orthopedic diseases: focusing on ferroptosis. Bone Res, 11(1):12.

[10]TangWY, MoreyLM, CheungYY, et al., 2012. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the ratprostate gland throughout life. Endocrinology, 153(1):‍42-55.

[11]WangXY, XieXM, ZhangYY, et al., 2022. Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma. Cell Oncol, 45(1):179-191.

[12]WuZM, GengY, LuXJ, et al., 2019. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci USA, 116(8):2996-3005.

[13]XieYC, HouT, LiuJY, et al., 2023. Autophagy-dependent ferroptosis as a potential treatment for glioblastoma. Front Oncol, 13:1091118.

[14]YangMH, ChenP, LiuJ, et al., 2019. Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv, 5(7):eaaw2238.

[15]ZhangDM, LiuXD, XuXB, et al., 2019. HPCAL1 promotes glioblastoma proliferation via activation of Wnt/β‍-catenin signalling pathway. J Cell Mol Med, 23(5):3108-3117.

[16]ZhangYL, LiuYF, DuanJL, et al., 2016. Hippocalcin-like 1 suppresses hepatocellular carcinoma progression by promoting p21Waf/Cip1 stabilization by activating the ERK1/2-MAPK pathway. Hepatology, 63(3):880-897.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE