CLC number: R542.2
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-04-18
Cited: 0
Clicked: 4845
Hui Zhou, Yan Chen, Shu-wei Huang, Peng-fei Hu, Li-jiang Tang. Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy[J]. Journal of Zhejiang University Science B, 2018, 19(5): 333-341.
@article{title="Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy",
author="Hui Zhou, Yan Chen, Shu-wei Huang, Peng-fei Hu, Li-jiang Tang",
journal="Journal of Zhejiang University Science B",
volume="19",
number="5",
pages="333-341",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700415"
}
%0 Journal Article
%T Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy
%A Hui Zhou
%A Yan Chen
%A Shu-wei Huang
%A Peng-fei Hu
%A Li-jiang Tang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 5
%P 333-341
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700415
TY - JOUR
T1 - Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy
A1 - Hui Zhou
A1 - Yan Chen
A1 - Shu-wei Huang
A1 - Peng-fei Hu
A1 - Li-jiang Tang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 5
SP - 333
EP - 341
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700415
Abstract: Objective: To investigate the effect of tea polyphenols on cardiac function in rats with diabetic cardiomyopathy, and the mechanism by which tea polyphenols regulate autophagy in diabetic cardiomyopathy. Methods: Sixty Sprague-Dawley (SD) rats were randomly divided into six groups: a normal control group (NC), an obesity group (OB), a diabetic cardiomyopathy group (DCM), a tea polyphenol group (TP), an obesity tea polyphenol treatment group (OB-TP), and a diabetic cardiomyopathy tea polyphenol treatment group (DCM-TP). After successful modeling, serum glucose, cholesterol, and triglyceride levels were determined; cardiac structure and function were inspected by ultrasonic cardiography; myocardial pathology was examined by staining with hematoxylin-eosin; transmission electron microscopy was used to observe the morphology and quantity of autophagosomes; and expression levels of autophagy-related proteins LC3-II, SQSTM1/p62, and Beclin-1 were determined by Western blotting. Results: Compared to the NC group, the OB group had normal blood glucose and a high level of blood lipids; both blood glucose and lipids were increased in the DCM group; ultrasonic cardiograms showed that the fraction shortening was reduced in the DCM group. However, these were improved significantly in the DCM-TP group. Hematoxylin-eosin staining showed disordered cardiomyocytes and hypertrophy in the DCM group; however, no differences were found among the remaining groups. Transmission electron microscopy revealed that the numbers of autophagosomes in the DCM and OB-TP groups were obviously increased compared to the NC and OB groups; the number of autophagosomes in the DCM-TP group was reduced. Western blotting showed that the expression of LC3-II/I and Beclin-1 increased obviously, whereas the expression of SQSTM1/p62 was decreased in the DCM and OB-TP groups (P<0.05). Conclusions: tea polyphenols had an effect on diabetic cardiomyopathy in rat cardiac function and may alter the levels of autophagy to improve glucose and lipid metabolism in diabetes.
[1]Chen C, Yang S, Li H, et al., 2017. Mir30c is involved in diabetic cardiomyopathy through regulation of cardiac autophagy via BECN1. Mol Ther Nucleic Acids, 7:127-139.
[2]Chung YR, Park SJ, Moon KY, et al., 2017. Diabetic retinopathy is associated with diastolic dysfunction in type 2 diabetic patients with non-ischemic dilated cardiomyopathy. Cardiovasc Diabetol, 16(1):82.
[3]Ding ML, Ma H, Man YG, et al., 2017. Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice. Can J Physiol Pharmacol, 95(12):1396-1405.
[4]Ding S, Jiang J, Yu P, 2017. Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy. PLoS ONE, 12(8):e0181666.
[5]Efeyan A, Comb WC, Sabatini DM, et al., 2015. Nutrient-sensing mechanisms and pathways. Nature, 517:302-310.
[6]Fahie K, Zachara NE, 2016. Molecular functions of glycoconjugates in autophagy. J Mol Bol, 428(16):3305-3324.
[7]Fan DM, Fan K, Yu CP, et al., 2017. Tea polyphenols dominate the short-term tea (Camellia sinensis) leaf litter decomposition. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(2):99-108.
[8]Gu W, Lin Y, Gou X, et al., 2017a. Tea polyphenol inhibits autophagy to sensitize epirubicin-induced apoptosis in human bladder cancer cells. Neoplasma, 64(05):674-680.
[9]Gu W, Yin H, Liu Y, et al., 2017b. The mechanism underlying the effects of tea polyphenol on epirubicin-induced autophagy and apoptosis in T24 bladder cancer cells. Chin J Cell Mol Immunol, 33(6):772-777 (in Chinese).
[10]Jaishy B, Abel ED, 2016. Lipids, lysosomes, and autophagy. J Lipid Res, 57(9):1619-1635.
[11]Kanamori H, Takemura G, Goto K, 2015. Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes. Autophagy, 11(7):1146-1160.
[12]Kubli DA, Gustafsson ÅB, 2015. Unbreak my heart: targeting mitochondrial autophagy in diabetic cardiomyopathy. Ann Surg Oncol, 22(17):1527-1544.
[13]Lai D, Gao J, Bi X, et al., 2017. The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling. J Mol Med, 95(2):155-165.
[14]Li HL, Li ZJ, Wei ZS, et al., 2015. Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(12):1019-1026.
[15]Lin C, Zhang M, Zhang Y, et al., 2017. Helix B surface peptide attenuates diabetic cardiomyopathy via AMPK-dependent autophagy. Biochem Biophys Res Commun, 482(4):665-671.
[16]Liu SM, Ou SY, Huang HH, 2017. Green tea polyphenols induce cell death in breast cancer MCF-7 cells through induction of cell cycle arrest and mitochondrial-mediated apoptosis. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(2):89-98.
[17]Nazio F, Cecconi F, 2017. Autophagy up and down by outsmarting the incredible ULK. Autophagy, 13(5):967-968.
[18]Ruiz M, Coderre L, Allen BG, et al., 2017. Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism. Biochim Biophys Acta, 39(17):30241-30247.
[19]Shin HR, Kim H, Kim KI, 2016. Epigenetic and transcriptional regulation of autophagy. Autophagy, 12(11):2248-2249.
[20]Singh R, Kaushik S, Wang Y, et al., 2009. Autophagy regulates lipid metabolism. Nature, 458(7242):1131-1135.
[21]Su HM, Feng LN, Zheng XD, et al., 2016. Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 17(6):437-446.
[22]Sun XH, Yin MS, Mu YL, 2016. Alterations of mTOR pathway and autophagy in early type 2 diabetic cardiomyopathy in rats. Chin J Pathol, 45(10):707-710 (in Chinese).
[23]Trivedi PC, Bartlett JJ, Perez LJ, et al., 2016. Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes. Biochim Biophys Acta, 1861(12):1893-1910.
[24]Velázquez AP, Graef M, 2016. Autophagy regulation depends on ER homeostasis controlled by lipid droplets. Autophagy, 12(8):1409-1410.
[25]Wang M, Zhang WB, Zhu JH, 2009. Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway. Acta Pharmacol Sin, 30(8):1081-1091.
[26]Wieczór R, Wieczór AM, Gadomska G, et al., 2016. Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 17(11):842-849.
[27]Xie X, Yi W, Zhang P, 2017. Green tea polyphenols, mimicking the effects of dietary restriction, ameliorate high-fat diet-induced kidney injury via regulating autophagy flux. Nutrients, 9(5):497.
[28]Yanagi S, Matsumura K, Marui A, et al., 2011. Oral pretreatment with a green tea polyphenol for cardioprotection against ischemia-reperfusion injury in an isolated rat heart model. J Thorac Cardiovasc Surg, 141(2):511-517.
[29]Yang Y, Rong X, Lv X, et al., 2017. Inhibition of mevalonate pathway prevents ischemia-induced cardiac dysfunction in rats via RhoA-independent signaling pathway. Cardiovasc Ther, 35(5):e12285.
[30]Yu HT, Zhen J, Pang B, et al., 2015. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(5):344-354.
[31]Zhang L, Ding WY, Wang ZH, et al., 2016. Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. J Transl Med, 14(1):109.
[32]Zhang PW, Tian C, Xu FY, et al., 2016. Green tea polyphenols alleviate autophagy inhibition induced by high glucose in endothelial cells. Biomed Environ Sci, 29(7):524-528.
[33]Zhao P, Kuai J, Gao J, et al., 2017. Delta opioid receptor agonist attenuates lipopolysaccharide-induced myocardial injury by regulating autophagy. Biochem Biophys Res Commun, 492(1):140-146.
[34]Zhuo C, Jiang R, Lin X, et al., 2017. LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy. Oncotarget, 8(1):1429-1437.
Open peer comments: Debate/Discuss/Question/Opinion
<1>