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CLC number: R654.2

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2018-04-18

Cited: 0

Clicked: 4238

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Qun Luo

https://orcid.org/0000-0001-6381-3146

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.5 P.342-348

http://doi.org/10.1631/jzus.B1700427


Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention


Author(s):  Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han

Affiliation(s):  Department of Cardiology, Ningbo No. 2 Hospital, Medical School of Ningbo University, Ningbo 315010, China; more

Corresponding email(s):   nbluoqun@163.com

Key Words:  Liver-type fatty acid-binding protein, Neutrophil gelatinase-associated lipocalin, Kidney injury molecule-1, Percutaneous coronary intervention, Acute kidney injury


Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han. Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention[J]. Journal of Zhejiang University Science B, 2018, 19(5): 342-348.

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author="Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han",
journal="Journal of Zhejiang University Science B",
volume="19",
number="5",
pages="342-348",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700427"
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%T Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention
%A Hong-Hua Ye
%A Gen Shen
%A Qun Luo
%A Fang-Fang Zhou
%A Xiao-Ling Xie
%A Chun-Yan Wang
%A Li-Na Han
%J Journal of Zhejiang University SCIENCE B
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T1 - Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention
A1 - Hong-Hua Ye
A1 - Gen Shen
A1 - Qun Luo
A1 - Fang-Fang Zhou
A1 - Xiao-Ling Xie
A1 - Chun-Yan Wang
A1 - Li-Na Han
J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1700427


Abstract: 
In aged patients, acute kidney injury (AKI) is a common clinical complication after percutaneous coronary intervention (PCI), highlighting the need for timely and certain diagnosis of this disease. A single centre, nested case-control study was conducted, which assessed the usefulness of urinary liver-type fatty acid-binding protein (uL-FABP), neutrophil gelatinase-associated lipocalin (uNGAL), and kidney injury molecule-1 (uKIM-1) for early detection of AKI. One hundred and thirty-two patients at or over 60 years old undergoing PCI were included. Serum creatinine (SCr) was measured before PCI, 24 and 48 h after PCI; uL-FABP, uNGAL, and uKIM-1 were measured before PCI, 6, 24, and 48 h after PCI. We identified 16 AKI patients and selected 32 control patients matched by admission time (<1 week), age (±5 years), and gender. In the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUCs) for the relative measurements of uL-FABP, uNGAL, and uKIM-1 were 0.809, 0.867, and 0.512 at 6 h after PCI, and 0.888, 0.840, and 0.676 at 24 h after PCI, respectively. AUC for the combination of uL-FABP and uNGAL was 0.899 at 6 h after PCI, and 0.917 at 24 h after PCI. Thus, measurement of uL-FABP and uNGAL levels at 6 and 24 h after PCI may be useful in detecting AKI in aged patients. Measurement of uKIM-1 levels provides inferior predictive power for early diagnosis of AKI.

老年患者经皮冠状动脉介入术后急性肾损伤的早期诊断的研究

目的:探索老年患者尿液中肝型脂肪酸结合蛋白(L-FABP)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及肾损伤分子1(KIM-1)三种新型肾损伤标志物对经皮冠状动脉介入(PCI)术后急性肾损伤(AKI)的早期预测作用.
创新点:本研究主要评估PCI术后肾损伤标志物的上升倍数对AKI早期诊断的价值,对基线标志物水平不同的患者而言,具有一定意义.
方法:采用巢式病例对照研究的方法来比较PCI术后AKI患者和对照组患者围手术期肾损伤标志物的变化.
结论:老年患者PCI术后6小时尿L-FABP和NGAL的上升倍数对AKI具有一定的预测价值.二者联合检验预测价值更高.而尿KIM-1的早期预测价值较低.

关键词:肝型脂肪酸结合蛋白;中性粒细胞明胶酶相关脂质运载蛋白;肾损伤分子1;经皮冠状动脉介入术;急性肾损伤

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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[22]List of electronic supplementary materials

[23]Data S1 Materials, methods, and declarations

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