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On-line Access: 2013-07-30

Received: 2013-07-01

Revision Accepted: 2013-07-15

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.713-720

http://doi.org/10.1631/jzus.BQICC706


A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention


Author(s):  Min Zhang, Hao-yu Meng, Ying-ming Zhao, Zhi-wen Tao, Xiao-xuan Gong, Ze-mu Wang, Bo Chen, Zheng-xian Tao, Chun-jian Li, Tie-bing Zhu, Lian-sheng Wang, Zhi-jian Yang

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding email(s):   zhijianyangnj@njmu.edu.cn

Key Words:  Percutaneous coronary intervention, Myonecrosis, Contrast-induced nephropathy, Acute kidney injury, Contrast media


Min Zhang, Hao-yu Meng, Ying-ming Zhao, Zhi-wen Tao, Xiao-xuan Gong, Ze-mu Wang, Bo Chen, Zheng-xian Tao, Chun-jian Li, Tie-bing Zhu, Lian-sheng Wang, Zhi-jian Yang. A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention[J]. Journal of Zhejiang University Science B, 2013, 14(8): 713-720.

@article{title="A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention",
author="Min Zhang, Hao-yu Meng, Ying-ming Zhao, Zhi-wen Tao, Xiao-xuan Gong, Ze-mu Wang, Bo Chen, Zheng-xian Tao, Chun-jian Li, Tie-bing Zhu, Lian-sheng Wang, Zhi-jian Yang",
journal="Journal of Zhejiang University Science B",
volume="14",
number="8",
pages="713-720",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.BQICC706"
}

%0 Journal Article
%T A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention
%A Min Zhang
%A Hao-yu Meng
%A Ying-ming Zhao
%A Zhi-wen Tao
%A Xiao-xuan Gong
%A Ze-mu Wang
%A Bo Chen
%A Zheng-xian Tao
%A Chun-jian Li
%A Tie-bing Zhu
%A Lian-sheng Wang
%A Zhi-jian Yang
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 8
%P 713-720
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.BQICC706

TY - JOUR
T1 - A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention
A1 - Min Zhang
A1 - Hao-yu Meng
A1 - Ying-ming Zhao
A1 - Zhi-wen Tao
A1 - Xiao-xuan Gong
A1 - Ze-mu Wang
A1 - Bo Chen
A1 - Zheng-xian Tao
A1 - Chun-jian Li
A1 - Tie-bing Zhu
A1 - Lian-sheng Wang
A1 - Zhi-jian Yang
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 8
SP - 713
EP - 720
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.BQICC706


Abstract: 
Slight elevations in cardiac troponin I and T are frequently observed after percutaneous coronary intervention (PCI). Contrast-induced acute kidney injury (CI-AKI) is a complex syndrome induced by exposure to intravascular contrast media (CM). Currently, the relationships between the CM, pre-existing kidney insufficiency, CI-AKI, and myonecrosis after elective PCI are unclear. To investigate the relationship between CI-AKI and post-procedural myonecrosis (PMN) after PCI, we analyzed 327 non-ST-segment elevation acute coronary syndrome subjects undertaking elective PCI. The levels of cardiac troponins (cTns), cTnI and cTnT, at baseline and on at least one occasion 18–24 h after PCI were measured. We also recorded serum levels of creatinine (SCr) and the urine albumin:creatinine ratio (ACR) before coronary angiography, and 24–48 h and 48–72 h after contrast administration. A post-procedure increase in cTns was detected in 16.21% (53/327) of subjects with cTns levels >99th to 5&time;99th percentile upper reference limit (URL). Twenty-seven patients (8.26%) developed CI-AKI. CI-AKI occurred more often in subjects with PMN than in those without PMN (20.8% versus 5.8%, respectively, P=0.001). Multiple logistic regression analysis revealed that pre-existing microalbuminuria (MA) was an important independent predictor of PMN (OR: 3.31; 95% CI: 1.26–8.65, P=0.01). However, there was no correlation between the incidence of CI-AKI and PMN (OR: 2.38; 95% CI: 0.88–6.46, P=0.09). We conclude that pre-existing MA was not only an important independent predictor of CI-AKI but also of PMN.

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