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On-line Access: 2013-07-30

Received: 2013-06-18

Revision Accepted: 2013-06-28

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.705-712

http://doi.org/10.1631/jzus.BQICC704


Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion


Author(s):  Zhen Sun, Ying Shen, Lin Lu, Rui-yan Zhang, Li-jin Pu, Qi Zhang, Zheng-kun Yang, Jian Hu, Qiu-jing Chen, Wei-feng Shen

Affiliation(s):  Department of Cardiology, Shanghai Ruijin Hospital, Shanghai 200025, China; more

Corresponding email(s):   rjshenweifeng@gmail.com

Key Words:  Stable angina, Coronary collateral circulation, Risk factors, Angiography, Chronic total coronary occlusion


Zhen Sun, Ying Shen, Lin Lu, Rui-yan Zhang, Li-jin Pu, Qi Zhang, Zheng-kun Yang, Jian Hu, Qiu-jing Chen, Wei-feng Shen. Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion[J]. Journal of Zhejiang University Science B, 2013, 14(8): 705-712.

@article{title="Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion",
author="Zhen Sun, Ying Shen, Lin Lu, Rui-yan Zhang, Li-jin Pu, Qi Zhang, Zheng-kun Yang, Jian Hu, Qiu-jing Chen, Wei-feng Shen",
journal="Journal of Zhejiang University Science B",
volume="14",
number="8",
pages="705-712",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.BQICC704"
}

%0 Journal Article
%T Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion
%A Zhen Sun
%A Ying Shen
%A Lin Lu
%A Rui-yan Zhang
%A Li-jin Pu
%A Qi Zhang
%A Zheng-kun Yang
%A Jian Hu
%A Qiu-jing Chen
%A Wei-feng Shen
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 8
%P 705-712
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.BQICC704

TY - JOUR
T1 - Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion
A1 - Zhen Sun
A1 - Ying Shen
A1 - Lin Lu
A1 - Rui-yan Zhang
A1 - Li-jin Pu
A1 - Qi Zhang
A1 - Zheng-kun Yang
A1 - Jian Hu
A1 - Qiu-jing Chen
A1 - Wei-feng Shen
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 8
SP - 705
EP - 712
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.BQICC704


Abstract: 
Objective: coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods: Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results: Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high collateralization (for all comparisons, P<0.05). In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein (hsCRP) compared with those with high collateralization. Multivariate analysis revealed that age of ≥65 years, female gender, diabetes, no history of hypertension, dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were independently associated with low coronary collateralization. Conclusions: Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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