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On-line Access: 2010-08-02

Received: 2010-06-13

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.8 P.575-582


Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention

Author(s):  Shu-qin Ying, Mei-xiang Xiang, Lu Fang, Jian-an Wang

Affiliation(s):  Department of Cardiology; more

Corresponding email(s):   xiangmx@yahoo.com

Key Words:  Percutaneous coronary intervention, Restenosis, Ischemia-reperfusion injury, P-selectin, Magnesium

Shu-qin Ying, Mei-xiang Xiang, Lu Fang, Jian-an Wang. Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention[J]. Journal of Zhejiang University Science B, 2010, 11(8): 575-582.

@article{title="Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention",
author="Shu-qin Ying, Mei-xiang Xiang, Lu Fang, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention
%A Shu-qin Ying
%A Mei-xiang Xiang
%A Lu Fang
%A Jian-an Wang
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 8
%P 575-582
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1001006

T1 - Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention
A1 - Shu-qin Ying
A1 - Mei-xiang Xiang
A1 - Lu Fang
A1 - Jian-an Wang
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 8
SP - 575
EP - 582
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1001006

Objective: This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention (PCI). Methods: The present study examined serial changes (5 min, 30 min, 2 h, 6 h, and 24 h after PCI) in circulating p-selectin, plasminogen activator inhibitor-1 (PAI-1), magnesium (Mg), and creatine kinase-myocardial band fraction (CK-MB) levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up. Results: PCI induced an early elevation of p-selectin, which correlated positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-1. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated p-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respectively. Conclusions: Our study demonstrates that PCI induces temporal changes of p-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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