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On-line Access: 2010-08-02

Received: 2010-06-11

Revision Accepted: 2010-06-27

Crosschecked: 2010-07-02

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.8 P.583-591


Effect of enalapril on plasma homocysteine levels in patients with essential hypertension

Author(s):  Fang-fang Fan, Yong Huo, Xu Wang, Xin Xu, Bin-yan Wang, Xi-ping Xu, Jian-ping Li

Affiliation(s):  Department of Cardiology, Peking University First Hospital, Beijing 100034, China, Institute of Biomedicine, Anhui Medical University, Hefei 230032, China

Corresponding email(s):   lijianping@medmail.com.cn

Key Words:  Essential hypertension, Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, Enalapril, Homocysteine

Fang-fang Fan, Yong Huo, Xu Wang, Xin Xu, Bin-yan Wang, Xi-ping Xu, Jian-ping Li. Effect of enalapril on plasma homocysteine levels in patients with essential hypertension[J]. Journal of Zhejiang University Science B, 2010, 11(8): 583-591.

@article{title="Effect of enalapril on plasma homocysteine levels in patients with essential hypertension",
author="Fang-fang Fan, Yong Huo, Xu Wang, Xin Xu, Bin-yan Wang, Xi-ping Xu, Jian-ping Li",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of enalapril on plasma homocysteine levels in patients with essential hypertension
%A Fang-fang Fan
%A Yong Huo
%A Xu Wang
%A Xin Xu
%A Bin-yan Wang
%A Xi-ping Xu
%A Jian-ping Li
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 8
%P 583-591
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1001003

T1 - Effect of enalapril on plasma homocysteine levels in patients with essential hypertension
A1 - Fang-fang Fan
A1 - Yong Huo
A1 - Xu Wang
A1 - Xin Xu
A1 - Bin-yan Wang
A1 - Xi-ping Xu
A1 - Jian-ping Li
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 8
SP - 583
EP - 591
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1001003

Objective: To investigate the effect of enalapril on plasma homocysteine (Hcy) levels and the association of Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with the changes of Hcy levels in response to enalapril among patients with essential hypertension. Methods: A total of 130 patients with mild-to-moderate essential hypertension were enrolled and enalapril was orally administered at a dose of 10 mg/d for eight weeks. Plasma Hcy levels were measured by denaturing high-performance liquid chromatography (DHPLC) at baseline and after eight weeks of treatment. Genotyping of MTHFR C677T polymorphism was performed by TaqMan probe technique. Results: Compared with baseline, plasma Hcy levels did not change significantly after eight weeks (P=0.81). Stratified by baseline Hcy levels, a significant increase in plasma Hcy levels (P=0.02) among those with Hcy <10 μmol/L was observed, in contrast to no significant changes in plasma Hcy levels (P=0.54) among those with Hcy ≥10 μmol/L. No significant association was observed between MTHFR C677T polymorphism and changes in Hcy levels in response to enalapril. Conclusions: enalapril may cause an increase in plasma Hcy levels among the hypertensives with low baseline Hcy levels. There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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