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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2024-02-02
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Citations: Bibtex RefMan EndNote GB/T7714
Xiangyu HONG, Junjie MA, Shanshan ZHENG, Guangyu ZHAO, Caiyun FU. Advances in the research and application of neurokinin-1 receptor antagonists[J]. Journal of Zhejiang University Science B, 2024, 25(2): 91-105.
@article{title="Advances in the research and application of neurokinin-1 receptor antagonists",
author="Xiangyu HONG, Junjie MA, Shanshan ZHENG, Guangyu ZHAO, Caiyun FU",
journal="Journal of Zhejiang University Science B",
volume="25",
number="2",
pages="91-105",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300455"
}
%0 Journal Article
%T Advances in the research and application of neurokinin-1 receptor antagonists
%A Xiangyu HONG
%A Junjie MA
%A Shanshan ZHENG
%A Guangyu ZHAO
%A Caiyun FU
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 2
%P 91-105
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300455
TY - JOUR
T1 - Advances in the research and application of neurokinin-1 receptor antagonists
A1 - Xiangyu HONG
A1 - Junjie MA
A1 - Shanshan ZHENG
A1 - Guangyu ZHAO
A1 - Caiyun FU
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 2
SP - 91
EP - 105
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300455
Abstract: Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis. These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor strategy. This review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers, as well as the underlying mechanisms. Furthermore, the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized, such as solid dispersion systems, nanonization, and nanoencapsulation. As a radiopharmaceutical therapeutic, the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing tumors. However, combining NK-1R antagonists with other drugs can produce a synergistic effect, thereby enhancing the therapeutic effect, alleviating the symptoms, and improving patients’ quality of life in several diseases and cancers.
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