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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300853


Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation


Author(s):  Liwen WANG, Huimei LIU, Lanfang LI

Affiliation(s):  Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China; more

Corresponding email(s):   2005001782@usc.edu.cn

Key Words:  Synthetic autophagy receptors, Autophagy, p62, Protein aggregates, Organelles


Liwen WANG, Huimei LIU, Lanfang LI. Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
Neurodegenerative diseases are genetic disorders of the central nervous system. Their key feature is the slow accumulation of misfolded protein deposits in brain neurons. While autophagy is known to play a crucial role in degrading protein aggregates, there is currently no effective and widely applicable method for the degradation of protein aggregates in mammalian cells. The latest data demonstrate that synthetic autophagy receptor-inspired targeting chimeras (AceTACs) act as degraders that can combine the LIR domain of the selective autophagy receptor-p62 with antibodies. Different protein aggregates (such as mHTT, TDP-43, and Tau) can be selectively targeted for disintegration by AceTAC degraders. Moreover, these degraders can target intracellular organelles including mitochondria, peroxisomes, and endoplasmic reticulum. Therefore, AceTACs represent promising autophagy-based targeted degraders that could offer a novel approach to effectively treat neurodegenerative diseases..

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