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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Boqing Zhang, Huan Sun, Lina Wu, Liang Ma, Fei Xing, Qingquan Kong, Yujiang Fan, Changchun Zhou, Xingdong Zhang. 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction[J]. Journal of Zhejiang University Science D, 2019, 2(3): 161-171.
@article{title="3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction",
author="Boqing Zhang, Huan Sun, Lina Wu, Liang Ma, Fei Xing, Qingquan Kong, Yujiang Fan, Changchun Zhou, Xingdong Zhang",
journal="Journal of Zhejiang University Science D",
volume="2",
number="3",
pages="161-171",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-019-00046-7"
}
%0 Journal Article
%T 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction
%A Boqing Zhang
%A Huan Sun
%A Lina Wu
%A Liang Ma
%A Fei Xing
%A Qingquan Kong
%A Yujiang Fan
%A Changchun Zhou
%A Xingdong Zhang
%J Journal of Zhejiang University SCIENCE D
%V 2
%N 3
%P 161-171
%@ 1869-1951
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-019-00046-7
TY - JOUR
T1 - 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction
A1 - Boqing Zhang
A1 - Huan Sun
A1 - Lina Wu
A1 - Liang Ma
A1 - Fei Xing
A1 - Qingquan Kong
A1 - Yujiang Fan
A1 - Changchun Zhou
A1 - Xingdong Zhang
J0 - Journal of Zhejiang University Science D
VL - 2
IS - 3
SP - 161
EP - 171
%@ 1869-1951
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-019-00046-7
Abstract: The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone repair. To satisfy these requirement, we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials (Ca-P bioceramics), which is expected to present a controllable biodegradation rate for patients who need bone regeneration. Physicochemical properties, porosity, compressive strength and degradation properties of the scaffolds were studied. 3D printed Ca-P scaffold (3DS), gas foaming Ca-P scaffold (FS) and autogenous bone (AB) were used in vivo for personalized beagle skull defect repair. Histological results indicated that the 3DS was highly vascularized and well combined with surrounding tissues. FS showed obvious newly formed bone tissues. AB showed the best repair effect, but it was found that AB scaffolds were partially absorbed and degraded. This study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction.
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