CLC number:
On-line Access: 2019-12-16
Received: 2019-10-07
Revision Accepted: 2019-12-04
Crosschecked: 2020-03-01
Cited: 0
Clicked: 2662
XiangjiaLi, YuanYuan, LuyangLiu, Yuen?ShanLeung, YiyuChen, YuxingGuo, YangChai, YongChen. 3D printing ofhydroxyapatite/tricalcium phosphate scafold withhierarchical porous structure forbone regeneration[J]. Journal of Zhejiang University Science D, 2020, 3(1): 15-29.
@article{title="3D printing ofhydroxyapatite/tricalcium phosphate scafold
withhierarchical porous structure forbone regeneration",
author="XiangjiaLi, YuanYuan, LuyangLiu, Yuen?ShanLeung, YiyuChen, YuxingGuo, YangChai, YongChen",
journal="Journal of Zhejiang University Science D",
volume="3",
number="1",
pages="15-29",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-019-00056-5"
}
%0 Journal Article
%T 3D printing ofhydroxyapatite/tricalcium phosphate scafold
withhierarchical porous structure forbone regeneration
%A XiangjiaLi
%A YuanYuan
%A LuyangLiu
%A Yuen?ShanLeung
%A YiyuChen
%A YuxingGuo
%A YangChai
%A YongChen
%J Journal of Zhejiang University SCIENCE D
%V 3
%N 1
%P 15-29
%@ 1869-1951
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-019-00056-5
TY - JOUR
T1 - 3D printing ofhydroxyapatite/tricalcium phosphate scafold
withhierarchical porous structure forbone regeneration
A1 - XiangjiaLi
A1 - YuanYuan
A1 - LuyangLiu
A1 - Yuen?ShanLeung
A1 - YiyuChen
A1 - YuxingGuo
A1 - YangChai
A1 - YongChen
J0 - Journal of Zhejiang University Science D
VL - 3
IS - 1
SP - 15
EP - 29
%@ 1869-1951
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-019-00056-5
Abstract: Three-dimensional (3D)-printed scafolds have attracted considerable attention in recent years as they provide a suitable
environment for bone cell tissue regeneration and can be customized in shape. Among many other challenges, the material
composition and geometric structure have major impacts on the performance of scafolds. Hydroxyapatite and tricalcium
phosphate (HA/TCP), as the major constituents of natural bone and teeth, possess attractive biological properties and are
widely used in bone scafold fabrication. Many fabrication methods have been investigated in attempts to achieve HA/TCP
scafolds with microporous structure enabling cell growth and nutrient transport. However, current 3D printing methods can
only achieve the fabrication of HA/TCP scafolds with certain range of microporous structure. To overcome this challenge,
we developed a slurry-based microscale mask image projection stereolithography, allowing us to form a HA/TCP-based
photocurable suspension with complex geometry including biomimetic features and hierarchical porosity. Here, the curing
performance and physical properties of the HA/TCP suspension were investigated, and a circular movement process for the
fabrication of highly viscous HA/TCP suspension was developed. Based on these investigations, the scafold composition
was optimized. We determined that a 30wt% HA/TCP scafold with biomimetic hierarchical structure exhibited superior
mechanical properties and porosity. Cell proliferation was investigated invitro, and the surgery was conducted in a nude
mouse invivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells. The results
showed our 3D-printed HA/TCP scafold with biomimetic hierarchical structure is biocompatible and has sufcient mechanical strength for surgery.
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