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CLC number: TH781

On-line Access: 2019-07-05

Received: 2018-12-14

Revision Accepted: 2019-03-13

Crosschecked: 2019-06-15

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Yun-feng Liu


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.8 P.647-659


Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications

Author(s):  Wen-ming Peng, Yun-feng Liu, Xian-feng Jiang, Xing-tao Dong, Janice Jun, Dale A. Baur, Jia-jie Xu, Hui Pan, Xu Xu

Affiliation(s):  Key Laboratory of E&M (Zhejiang University of Technology), Ministry of Education & Zhejiang Province, Hangzhou 310023, China; more

Corresponding email(s):   liuyf76@126.com, xfjiang@zjut.edu.cn

Key Words:  Layered slice and rod-connected mesh structure (LSRCMS), Porous Ti6Al4V implant, Bone defect repair, Selective laser melting (SLM), Mechanical properties, Finite element analysis

Wen-ming Peng, Yun-feng Liu, Xian-feng Jiang, Xing-tao Dong, Janice Jun, Dale A. Baur, Jia-jie Xu, Hui Pan, Xu Xu. Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications[J]. Journal of Zhejiang University Science B, 2019, 20(8): 647-659.

@article{title="Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications",
author="Wen-ming Peng, Yun-feng Liu, Xian-feng Jiang, Xing-tao Dong, Janice Jun, Dale A. Baur, Jia-jie Xu, Hui Pan, Xu Xu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications
%A Wen-ming Peng
%A Yun-feng Liu
%A Xian-feng Jiang
%A Xing-tao Dong
%A Janice Jun
%A Dale A. Baur
%A Jia-jie Xu
%A Hui Pan
%A Xu Xu
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 8
%P 647-659
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800622

T1 - Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications
A1 - Wen-ming Peng
A1 - Yun-feng Liu
A1 - Xian-feng Jiang
A1 - Xing-tao Dong
A1 - Janice Jun
A1 - Dale A. Baur
A1 - Jia-jie Xu
A1 - Hui Pan
A1 - Xu Xu
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 8
SP - 647
EP - 659
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800622

In maxillofacial surgery, there is a significant need for the design and fabrication of porous scaffolds with customizable bionic structures and mechanical properties suitable for bone tissue engineering. In this paper, we characterize the porous Ti6Al4V implant, which is one of the most promising and attractive biomedical applications due to the similarity of its modulus to human bones. We describe the mechanical properties of this implant, which we suggest is capable of providing important biological functions for bone tissue regeneration. We characterize a novel bionic design and fabrication process for porous implants. A design concept of “reducing dimensions and designing layer by layer” was used to construct layered slice and rod-connected mesh structure (LSRCMS) implants. Porous LSRCMS implants with different parameters and porosities were fabricated by selective laser melting (SLM). Printed samples were evaluated by microstructure characterization, specific mechanical properties were analyzed by mechanical tests, and finite element analysis was used to digitally calculate the stress characteristics of the LSRCMS under loading forces. Our results show that the samples fabricated by SLM had good structure printing quality with reasonable pore sizes. The porosity, pore size, and strut thickness of manufactured samples ranged from (60.95± 0.27)% to (81.23±0.32)%, (480±28) to (685±31) μm, and (263±28) to (265±28) μm, respectively. The compression results show that the Young’s modulus and the yield strength ranged from (2.23±0.03) to (6.36±0.06) GPa and (21.36±0.42) to (122.85±3.85) MPa, respectively. We also show that the Young’s modulus and yield strength of the LSRCMS samples can be predicted by the Gibson-Ashby model. Further, we prove the structural stability of our novel design by finite element analysis. Our results illustrate that our novel SLM-fabricated porous Ti6Al4V scaffolds based on an LSRCMS are a promising material for bone implants, and are potentially applicable to the field of bone defect repair.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Ahmadi SM, Campoli G, Yavari SA, et al., 2014. Mechanical behavior of regular open-cell porous biomaterials made of diamond lattice unit cells. J Mech Behav Biomed Mater, 34:106-115.

[2]Ajdari A, Jahromi BH, Papadopoulos J, et al., 2012. Hierarchical honeycombs with tailorable properties. Int J Solids Struct, 49(11-12):1413-1419.

[3]Arabnejad S, Johnston RB, Pura JA, et al., 2016. High-strength porous biomaterials for bone replacement: a strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints. Acta Biomater, 30:345-356.

[4]Arabnejad S, Johnston B, Tanzer M, et al., 2017. Fully porous 3D printed titanium femoral stem to reduce stress-shielding following total hip arthroplasty. J Orthop Res, 35(8):1774-1783.

[5]Ataee A, Li YC, Fraser D, et al., 2018. Anisotropic Ti-6Al-4V gyroid scaffolds manufactured by electron beam melting (EBM) for bone implant applications. Mater Design, 137: 345-354.

[6]Attar H, Löber L, Funk A, et al., 2015. Mechanical behavior of porous commercially pure Ti and Ti-TiB composite materials manufactured by selective laser melting. Mater Sci Eng A, 625:350-356.

[7]Banse X, Devogelaer JP, Munting E, et al., 2001. Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body. Bone, 28(5):563-571.

[8]Bernard S, Grimal Q, Laugier P, 2013. Accurate measurement of cortical bone elasticity tensor with resonant ultrasound spectroscopy. J Mech Behav Biomed Mater, 18:12-19.

[9]Bobbert FSL, Lietaert K, Eftekhari AA, et al., 2017. Additively manufactured metallic porous biomaterials based on minimal surfaces: a unique combination of topological, mechanical, and mass transport properties. Acta Biomater, 53:572-584.

[10]Bose S, Vahabzadeh S, Bandyopadhyay A, 2013. Bone tissue engineering using 3D printing. Mater Today, 16(12):496-504.

[11]Chen SY, Huang JC, Pan CT, et al., 2017. Microstructure and mechanical properties of open-cell porous Ti-6Al-4V fabricated by selective laser melting. J Alloys Compd, 713: 248-254.

[12]Choy SY, Sun CN, Leong KF, et al., 2017. Compressive properties of functionally graded lattice structures manufactured by selective laser melting. Mater Design, 131: 112-120.

[13]Gepreel MAH, Niinomi M, 2013. Biocompatibility of Ti-alloys for long-term implantation. J Mech Behav Biomed Mater, 20:407-415.

[14]Giannitelli SM, Accoto D, Trombetta M, et al., 2014. Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomater, 10(2):580-594.

[15]Gibson LJ, Ashby MF, 1997. Cellular Solids: Structure and Properties, 2nd Ed. Cambridge University Press, Cambridge, UK, p.510.

[16]Gorny B, Niendorf T, Lackmann J, et al., 2011. In situ characterization of the deformation and failure behavior of non-stochastic porous structures processed by selective laser melting. Mater Sci Eng A, 528(27):7962-7967.

[17]Gümrük R, Mines RAW, Karadeniz S, 2013. Static mechanical behaviours of stainless steel micro-lattice structures under different loading conditions. Mater Sci Eng A, 586:392-406.

[18]Han CJ, Yan CZ, Wen SF, et al., 2017. Effects of the unit cell topology on the compression properties of porous Co-Cr scaffolds fabricated via selective laser melting. Rapid Prototyp J, 23(1):16-27.

[19]Han CJ, Li Y, Wang Q, et al., 2018. Continuous functionally graded porous titanium scaffolds manufactured by selective laser melting for bone implants. J Mech Behav Biomed Mater, 80:119-127.

[20]Harrysson OLA, Cansizoglu O, Marcellin-Little DJ, et al., 2008. Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology. Mater Sci Eng C Mater Biol Appl, 28(3):366-373.

[21]Hazlehurst KB, Wang CJ, Stanford M, 2014. An investigation into the flexural characteristics of functionally graded cobalt chrome femoral stems manufactured using selective laser melting. Mater Design, 60:177-183.

[22]Hedayati R, Hosseini-Toudeshky H, Sadighi M, et al., 2016. Computational prediction of the fatigue behavior of additively manufactured porous metallic biomaterials. Int J Fatigue, 84:67-79.

[23]Henriksson I, Gatenholm P, Hägg DA, 2017. Increased lipid accumulation and adipogenic gene expression of adipocytes in 3D bioprinted nanocellulose scaffolds. Biofabrication, 9(1):015022.

[24]Horn TJ, Harrysson OLA, Marcellin-Little DJ, et al., 2014. Flexural properties of Ti6Al4V rhombic dodecahedron open cellular structures fabricated with electron beam melting. Addit Manuf, 1-4:2-11.

[25]International Organization for Standardization, 2011. Mechanical Testing of Metals—Ductility Testing—Compression Test for Porous and Cellular Metals, ISO 13314:2011. International Organization for Standardization, Switzerland.

[26]Jiang GF, He G, 2014. Enhancement of the porous titanium with entangled wire structure for load-bearing biomedical applications. Mater Design, 56:241-244.

[27]Jung HD, Yook SW, Jang TS, et al., 2013. Dynamic freeze casting for the production of porous titanium (Ti) scaffolds. Mater Sci Eng C Mater Biol Appl, 33(1):59-63.

[28]Kadkhodapour J, Montazerian H, Raeisi S, 2014. Investigating internal architecture effect in plastic deformation and failure for TPMS-based scaffolds using simulation methods and experimental procedure. Mater Sci Eng C Mater Biol Appl, 43:587-597.

[29]Kadkhodapour J, Montazerian H, Darabi AC, et al., 2015. Failure mechanisms of additively manufactured porous biomaterials: effects of porosity and type of unit cell. J Mech Behav Biomed Mater, 50:180-191.

[30]Kadkhodapour J, Montazerian H, Darabi AC, et al., 2017. The relationships between deformation mechanisms and mechanical properties of additively manufactured porous biomaterials. J Mech Behav Biomed Mater, 70:28-42.

[31]Levine BR, Sporer S, Poggie RA, et al., 2006. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials, 27(27):4671-4681.

[32]Li PF, 2015. Constitutive and failure behaviour in selective laser melted stainless steel for microlattice structures. Mater Sci Eng A, 622:114-120.

[33]Melancon D, Bagheri ZS, Johnston RB, et al., 2017. Mechanical characterization of structurally porous biomaterials built via additive manufacturing: experiments, predictive models, and design maps for load-bearing bone replacement implants. Acta Biomater, 63:350-368.

[34]Qin M, Liu YX, Wang L, et al., 2015. Design and optimization of the fixing plate for customized mandible implants. J Craniomaxillofac Surg, 43(7):1296-1302.

[35]Ravari MRK, Kadkhodaei M, Badrossamay M, et al., 2014. Numerical investigation on mechanical properties of cellular lattice structures fabricated by fused deposition modeling. Int J Mech Sci, 88:154-161.

[36]Smith M, Guan Z, Cantwell WJ, 2013. Finite element modelling of the compressive response of lattice structures manufactured using the selective laser melting technique. Int J Mech Sci, 67:28-41.

[37]Sun JF, Yang YQ, Wang D, 2013. Mechanical properties of a Ti6Al4V porous structure produced by selective laser melting. Mater Design, 49:545-552.

[38]Surmeneva MA, Surmenev RA, Chudinova EA, et al., 2017. Fabrication of multiple-layered gradient cellular metal scaffold via electron beam melting for segmental bone reconstruction. Mater Design, 133:195-204.

[39]van Bael S, Chai YC, Truscello S, et al., 2012. The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds. Acta Biomater, 8(7):2824-2834.

[40]Wang XJ, Xu SQ, Zhou SW, et al., 2016. Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review. Biomaterials, 83:127-141.

[41]Yan CZ, Hao L, Hussein A, et al., 2015. Ti-6Al-4V triply periodic minimal surface structures for bone implants fabricated via selective laser melting. J Mech Behav Biomed Mater, 51:61-73.

[42]Yánez A, Cuadrado A, Martel O, et al., 2018. Gyroid porous titanium structures: a versatile solution to be used as scaffolds in bone defect reconstruction. Mater Design, 140:21-29.

[43]Yavari SA, Ahmadi SM, Wauthle R, et al., 2015. Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials. J Mech Behav Biomed Mater, 43:91-100.

[44]Zargarian A, Esfahanian M, Kadkhodapour J, et al., 2014. Effect of solid distribution on elastic properties of open-cell cellular solids using numerical and experimental methods. J Mech Behav Biomed Mater, 37:264-273.

[45]Zargarian A, Esfahanian M, Kadkhodapour J, et al., 2016. Numerical simulation of the fatigue behavior of additive manufactured titanium porous lattice structures. Mater Sci Eng C Mater Biol Appl, 60:339-347.

[46]Zhang BQ, Pe X, Zhou CC, et al., 2018. The biomimetic design and 3D printing of customized mechanical properties porous Ti6Al4V scaffold for load-bearing bone reconstruction. Mater Design, 152:30-39.

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