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CLC number: TH781

On-line Access: 2019-07-05

Received: 2018-12-14

Revision Accepted: 2019-03-13

Crosschecked: 2019-06-15

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yun-feng Liu

https://orcid.org/0000-0001-8487-0078

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.8 P.647-659

http://doi.org/10.1631/jzus.B1800622


Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications


Author(s):  Wen-ming Peng, Yun-feng Liu, Xian-feng Jiang, Xing-tao Dong, Janice Jun, Dale A. Baur, Jia-jie Xu, Hui Pan, Xu Xu

Affiliation(s):  Key Laboratory of E&M (Zhejiang University of Technology), Ministry of Education & Zhejiang Province, Hangzhou 310023, China; more

Corresponding email(s):   liuyf76@126.com, xfjiang@zjut.edu.cn

Key Words:  Layered slice and rod-connected mesh structure (LSRCMS), Porous Ti6Al4V implant, Bone defect repair, Selective laser melting (SLM), Mechanical properties, Finite element analysis


Wen-ming Peng, Yun-feng Liu, Xian-feng Jiang, Xing-tao Dong, Janice Jun, Dale A. Baur, Jia-jie Xu, Hui Pan, Xu Xu. Bionic mechanical design and 3D printing of novel porous Ti6Al4V implants for biomedical applications[J]. Journal of Zhejiang University Science B, 2019, 20(8): 647-659.

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journal="Journal of Zhejiang University Science B",
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pages="647-659",
year="2019",
publisher="Zhejiang University Press & Springer",
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A1 - Janice Jun
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Abstract: 
In maxillofacial surgery, there is a significant need for the design and fabrication of porous scaffolds with customizable bionic structures and mechanical properties suitable for bone tissue engineering. In this paper, we characterize the porous Ti6Al4V implant, which is one of the most promising and attractive biomedical applications due to the similarity of its modulus to human bones. We describe the mechanical properties of this implant, which we suggest is capable of providing important biological functions for bone tissue regeneration. We characterize a novel bionic design and fabrication process for porous implants. A design concept of “reducing dimensions and designing layer by layer” was used to construct layered slice and rod-connected mesh structure (LSRCMS) implants. Porous LSRCMS implants with different parameters and porosities were fabricated by selective laser melting (SLM). Printed samples were evaluated by microstructure characterization, specific mechanical properties were analyzed by mechanical tests, and finite element analysis was used to digitally calculate the stress characteristics of the LSRCMS under loading forces. Our results show that the samples fabricated by SLM had good structure printing quality with reasonable pore sizes. The porosity, pore size, and strut thickness of manufactured samples ranged from (60.95± 0.27)% to (81.23±0.32)%, (480±28) to (685±31) μm, and (263±28) to (265±28) μm, respectively. The compression results show that the Young’s modulus and the yield strength ranged from (2.23±0.03) to (6.36±0.06) GPa and (21.36±0.42) to (122.85±3.85) MPa, respectively. We also show that the Young’s modulus and yield strength of the LSRCMS samples can be predicted by the Gibson-Ashby model. Further, we prove the structural stability of our novel design by finite element analysis. Our results illustrate that our novel SLM-fabricated porous Ti6Al4V scaffolds based on an LSRCMS are a promising material for bone implants, and are potentially applicable to the field of bone defect repair.

用于生物医学的新型多孔Ti6Al4V植入物的仿生设计和3D打印

目的:多孔结构植入体在骨科修复领域具有极大的应用前景.本研究提出了一种在结构与力学性能方面更贴近人体骨组织的多孔Ti6Al4V植入体.
创新点:针对骨组织的结构特点,提出了"分层设计"理念,以期更好地模拟皮质骨和松质骨的结构.除了结构相似以外,这种植入体在力学性能和结构稳定性方面同样具有优势.
方法:将传统多孔植入体三维晶胞设计方法转化为二维设计理念,设计出一种分层杆连接多孔结构,并利用选择性激光熔融(SLM)技术打印出样品;然后通过光学显微镜评测打印效果,利用单轴压缩试验研究分析样品的力学性能;最后利用有限元方法分析多孔结构的结构稳定性.
结论:本研究所设计的新型分层杆连接结构可以通过SLM实现高质量的打印,且尺寸合理,力学性能与骨组织相接近,结构稳定性优于传统多孔结构.这种新型多孔结构植入体在骨缺损修复领域具有较好的潜在应用前景.

关键词:分层片状杆连接多孔结构(LSRCMS);多孔Ti6Al4V植入体;骨缺损修复;选择性激光熔融(SLM);机械性能;有限元分析

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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