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On-line Access: 2022-07-01

Received: 2021-09-03

Revision Accepted: 2022-02-13

Crosschecked: 2022-03-11

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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.627-632

http://doi.org/10.1007/s42242-022-00193-4


Future directions for research on tissue-engineered trachea


Author(s):  Hai Tang, Weiyan Sun, Yi Chen, Yunlang She & Chang Chen

Affiliation(s):  Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; more

Corresponding email(s):   chenthoracic@163.com

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Hai Tang, Weiyan Sun, Yi Chen, Yunlang She & Chang Chen. Future directions for research on tissue-engineered trachea[J]. Journal of Zhejiang University Science D, 2022, 5(3): 627-632.

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Abstract: 

同济大学附属肺科医院陈昶等 | 组织工程气管的研究展望

本观点论文聚焦组织工程气管未来研究方向。气管作为空气进入肺部的唯一途径,在空气的传导、清洁、湿润等方面起着不可或缺的作用。肿瘤、外伤和先天性气管疾病对患者是严重的威胁。对于广泛的气管疾病,手术切除后的气管重建是唯一的治疗方法,组织工程气管替代物在这一过程中存在巨大潜力。本文总结了临床前研究中使用的各种策略,其中脱细胞、3D打印、静电纺丝和模型铸造是常用的构建方法。此外,本文还提出了组织工程气管重建成功需要解决的关键问题,包括组织工程气管力学性能、快速充足血管化、周围免疫微环境稳态和与受体同步发育等。在此基础上,文章还总结了组织工程气管领域目前发展现状,并提出了未来发展的可能方向。

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