CLC number:
On-line Access: 2022-10-13
Received: 2022-05-09
Revision Accepted: 2022-09-08
Crosschecked: 0000-00-00
Cited: 0
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Weiying Lu, Yang Shi & Zhijian Xie. Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis[J]. Journal of Zhejiang University Science D, 2023, 6(1): 51-73.
@article{title="Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis",
author="Weiying Lu, Yang Shi & Zhijian Xie",
journal="Journal of Zhejiang University Science D",
volume="6",
number="1",
pages="51-73",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00212-4"
}
%0 Journal Article
%T Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis
%A Weiying Lu
%A Yang Shi & Zhijian Xie
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 1
%P 51-73
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00212-4
TY - JOUR
T1 - Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis
A1 - Weiying Lu
A1 - Yang Shi & Zhijian Xie
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 1
SP - 51
EP - 73
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00212-4
Abstract: Large bone defect regeneration has always been recognized as a challenging clinical problem due to the difficulty of revascularization. Conventional treatments exhibit certain inherent disadvantages (e.g., secondary injury, immunization, and potential infections). However, three-dimensional (3D) printing technology as an emerging field can serve as an effective approach to achieve satisfactory revascularization while making up for the above limitations. A wide variety of methods can be used to facilitate blood supply during the design of a 3D-printed scaffold. Importantly, the scaffold structure lays a foundation for the entire printing object; any method to promote angiogenesis can be effective only if it is based on well-designed scaffolds. In this review, different designs related to angiogenesis are summarized by collecting the literature from recent years. The 3D-printed scaffolds are classified into four major categories and discussed in detail, from elementary porous scaffolds to the most advanced bone-like scaffolds. Finally, structural design suggestions to achieve rapid angiogenesis are proposed by analyzing the above architectures. This review can provide a reference for organizations or individual academics to achieve improved bone defect repair and regeneration using 3D printing.
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