JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.5 P.361-366

MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis

Author(s): Qiu-ping Xie, Cheng Xiang, Gang Wang, Ke-feng Lei, Yong Wang
Affiliation(s): Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more
Corresponding email(s): yushengxqp@yeah.net, drchengxiang@126.com, Surgwy@163.com
Key Words: Gastric cancer, MACC1, Prognosis, Metastasis

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Abstract: In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution in GC samples with distant metastasis was higher than that in normal samples and in tumors with no dissemination. Subsequently, a lower 5-year survival rate had a strong correlation with high MACC1 expression. As a consequence, the present results suggest that MACC1 is more frequently expressed in a poor prognosis phenotype of GC and acts as a promising prognostic prediction parameter for GC.

MACC1高表达促进胃癌的转移，缩短患者生存时间

目的：评估MACC1基因在胃癌发生发展中的作用。
创新点：首次发现胃癌中MACC1基因高表达，并且在患者标本中发现高表达MACC1和胃癌的远处转移和预后有显著相关性。
方法：使用免疫组化的方法对105例胃癌患者进行分析，并且将MACC1和其临床特点包括年龄、肿瘤大小、肿瘤分化以及远处转移状况进行归纳和显著性检验，进一步将患者分为MACC1高表达和低表达组。通过定期的随访，绘制患者生存曲线。
结论：本实验中发现了在胃癌远处转移灶组织中MACC1表达显著升高。然而MACC1的高表达和胃癌的肿瘤大小、肿瘤分化等特性未见明显相关性。同时胃癌患者的5年生存率和MACC1的高表达有显著性关联。

关键词：胃癌；MACC1；预后；远处转移

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MACC1高表达促进胃癌的转移，缩短患者生存时间

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