Full Text:   <2452>

Summary:  <1881>

CLC number: R735.2

On-line Access: 2016-05-04

Received: 2015-09-27

Revision Accepted: 2015-12-27

Crosschecked: 2016-04-15

Cited: 3

Clicked: 4304

Citations:  Bibtex RefMan EndNote GB/T7714


Qiu-ping Xie


Yong Wang


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.5 P.361-366


MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis

Author(s):  Qiu-ping Xie, Cheng Xiang, Gang Wang, Ke-feng Lei, Yong Wang

Affiliation(s):  Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   yushengxqp@yeah.net, drchengxiang@126.com, Surgwy@163.com

Key Words:  Gastric cancer, MACC1, Prognosis, Metastasis

Qiu-ping Xie, Cheng Xiang, Gang Wang, Ke-feng Lei, Yong Wang. MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis[J]. Journal of Zhejiang University Science B, 2016, 17(5): 361-366.

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author="Qiu-ping Xie, Cheng Xiang, Gang Wang, Ke-feng Lei, Yong Wang",
journal="Journal of Zhejiang University Science B",
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%0 Journal Article
%T MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis
%A Qiu-ping Xie
%A Cheng Xiang
%A Gang Wang
%A Ke-feng Lei
%A Yong Wang
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500236

T1 - MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis
A1 - Qiu-ping Xie
A1 - Cheng Xiang
A1 - Gang Wang
A1 - Ke-feng Lei
A1 - Yong Wang
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 5
SP - 361
EP - 366
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500236

In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution in GC samples with distant metastasis was higher than that in normal samples and in tumors with no dissemination. Subsequently, a lower 5-year survival rate had a strong correlation with high MACC1 expression. As a consequence, the present results suggest that MACC1 is more frequently expressed in a poor prognosis phenotype of GC and acts as a promising prognostic prediction parameter for GC.

This manuscript is submitted by an established clinical patient group with a history of working on the pathology and prognosis of gastric cancer. The experiments were logically designed; the conclusion is supported by the very nice experiment and detailed follow-up.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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