JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.1022-1025

Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization

Author(s): Miao Li, Jia-lun Song, Ying Zhao, She-ling Wu, Hong-bin Liu, Rong Tang, Lei Yan
Affiliation(s): Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China; more
Corresponding email(s): yanleiandu@163.com
Key Words: Progestin therapy, Endometrial hyperplasia, In vitro fertilization

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Abstract: This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes. The World Health Organization (WHO) classified it into four types: simple or complex hyperplasia with or without atypia. CH is characterized by glands with irregular outlines that demonstrate marked structural complexity and back-to-back crowding. Atypical hyperplasia designates a proliferation of glands exhibiting cytologic atypia, in which varying degrees of nuclear atypia and loss of polarity are present. It has been reported that high-dose progestin is safe and efficient for CAH or early-stage low-grade carcinoma for young women who desire fertility-preserving treatment. However, few studies have reported the differences of pregnancy outcomes between patients with CAH and CH, while those patients take a great proportion in people suffered from infertility. More studies about the outcome of IVF are needed. Our aim is to evaluate fertility and oncological outcomes in women with CH or CAH who received fertility-sparing therapy.

子宫内膜不典型增生或复杂性增生不孕患者孕激素和IVF后的妊娠结局分析

概要：本回顾性队列研究包括了年龄在45岁以下被诊断为伴有或不伴有不典型增生的子宫内膜复杂性增生患者，对孕激素治疗后的临床结局及妊娠结局进行了比较。结果表明，伴有或不伴有不典型增生的子宫内膜复杂性增生接受孕激素治疗后，其临床及妊娠结局并没有显著差异。我们认为对于这些患者，在短暂的孕激素治疗控制病情后，尽快施行体外受精-胚胎移植治疗（IVF）将有利于改善其妊娠结局。

关键词：孕激素治疗；子宫内膜增生；体外受精-胚胎移植治疗（IVF）

Reference

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子宫内膜不典型增生或复杂性增生不孕患者孕激素和IVF后的妊娠结局分析

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