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Yujuan CHEN, Junhong LIN, Yao ZHAO, Xianping MA, Huashan YI. Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses[J]. Journal of Zhejiang University Science B, 2021, 22(8): 609-632.
@article{title="Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses",
author="Yujuan CHEN, Junhong LIN, Yao ZHAO, Xianping MA, Huashan YI",
journal="Journal of Zhejiang University Science B",
volume="22",
number="8",
pages="609-632",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000808"
}
%0 Journal Article
%T Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
%A Yujuan CHEN
%A Junhong LIN
%A Yao ZHAO
%A Xianping MA
%A Huashan YI
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 8
%P 609-632
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000808
TY - JOUR
T1 - Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
A1 - Yujuan CHEN
A1 - Junhong LIN
A1 - Yao ZHAO
A1 - Xianping MA
A1 - Huashan YI
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 8
SP - 609
EP - 632
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000808
Abstract: toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the toll-interleukin-1 receptor (TIR);-domain-containing adaptor-inducing IFN-β;(TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear. In this review, we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects. Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases.
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