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Bio-Design and Manufacturing  2019 Vol.2 No.4 P.439~444

10.1631/jzus.2001.0439


LONG-TERM INHIBITION OF Na+/H+ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS


Author(s):  XIA Qin-gui, Oliver Chung, Heidi Spitznagel, Thomas Unger

Affiliation(s):  Institute of Pharmacology, Christian-Albrechts-University of Kiel, Hospitalstrasse 4, 24105 Kiel, Germany

Corresponding email(s):   q.xia@pharmakologie.uni-kiel.de

Key Words:  myocardial infarction, Na+/H+ exchange inhibitor, remodeling, ventricular function


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XIA Qin-gui, Oliver Chung, Heidi Spitznagel, Thomas Unger. LONG-TERM INHIBITION OF Na+/H+ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS[J]. Journal of Zhejiang University Science D, 2019, 2(4): 439~444.

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author="XIA Qin-gui, Oliver Chung, Heidi Spitznagel, Thomas Unger",
journal="Journal of Zhejiang University Science D",
volume="2",
number="4",
pages="439~444",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2001.0439"
}

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%T LONG-TERM INHIBITION OF Na+/H+ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS
%A XIA Qin-gui
%A Oliver Chung
%A Heidi Spitznagel
%A Thomas Unger
%J Journal of Zhejiang University SCIENCE D
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%P 439~444
%@ 1869-1951
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2001.0439

TY - JOUR
T1 - LONG-TERM INHIBITION OF Na+/H+ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS
A1 - XIA Qin-gui
A1 - Oliver Chung
A1 - Heidi Spitznagel
A1 - Thomas Unger
J0 - Journal of Zhejiang University Science D
VL - 2
IS - 4
SP - 439
EP - 444
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Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2001.0439


Abstract: 
Objective: In addition to pH regulation, Na+/H+ exchanger (NIE) has been shown to facilitate cell growth and proliferation. However, the effects of long-term inhibition of Na+/H+ exchange on cardiac structural and functional remodeling post myocardial infarction (MI) are still controversial. The present study was therefore carried ont to further investigate the effects of long-term treatment with cariporide, a specific inhibitor of NHE-1, on cardiac remodeling after MI in rots; Methods: Male Wistar rots that underwent coronary ligation were randomly selected for cariporide treatment starting 6 h after induction of MI or no treatment. Treatment was continued up to 6 weeks post MI, after which, the arterial, venous and left ventricular catheters were chronically implanted. Twenty-four h later, after hemodynamic signals were recorded in conscious rats, they were sacrificed and hearts were taken out for morphological examinations; Results: Cariporide treatment decreased the heart weight and heart weight to body weight ratio (both P<0.05), decreased left ventricular end-diastohc pressure (P<0.001), improved myocardial contractility (dP/dtmax) (P<0.05) and tended to increase the survival of treated rots compared to that of untreated infarct rats; Conclusion: The results of the present study indicate that the long-term inhibition of NHE with cariporide can attenuate cardiac structural re-modeling and improve left ventricular dysfunction in infarcted rats, and suggest that Na+/H+ exchange inhibition could be an effective therapeutic strategy for myocardial infarction-induced heart failure.

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