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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.2 P.242-245


Distribution of H. pylori antigens in gastric mucosa and its significance

Author(s):  LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang

Affiliation(s):  Department of Gastroenterology, the Second Affiliated Hospital, clollege of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   xl_lu@hotmail.com.cn

Key Words:  Helicobacter pylori, Immunohistochemistry, Antigen, Gastric cancer, Precancerous change

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LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang. Distribution of H. pylori antigens in gastric mucosa and its significance[J]. Journal of Zhejiang University Science A, 2004, 5(2): 242-245.

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author="LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang",
journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Distribution of H. pylori antigens in gastric mucosa and its significance
%A LU Xin-liang
%A QIAN Ke-da
%A TANG Xun-qiu
%A ZHU Yong-liang
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 2
%P 242-245
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0242

T1 - Distribution of H. pylori antigens in gastric mucosa and its significance
A1 - LU Xin-liang
A1 - QIAN Ke-da
A1 - TANG Xun-qiu
A1 - ZHU Yong-liang
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 242
EP - 245
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0242

Objective: To investigate the distribution of H. pylori antigens in the gastric mucosa in patients with H. pylori infection, and the relationship between the distribution and gastric cancer. Methods: Of 112 patients confirmed by pathological study to have chronic superficial gastritis, precancerous changes (chronic atrophic gastritis, intestinal metaplasia or atypical hyperplasia) and gastric cancer, 28 were H. pylori negative and 84 were H. pyloripositive. H. pylori antigens in the gastric mucosa were detected by immunohistochemistry. Results: The H.pylori positive group, comprised 12 of 22 (50.0%) in the chronic superficial gastritis group, 22 of 25 (88.0%) in the precancerous changes group and 13 of 35 (37.1%) in the gastric cancer group. The positive rates of H. pylori antigens in the cytoplasm progressively increased, respectively at 0.0% (0/12), 63.6% (14/22) and 84.6% (11/13) for the same groups (χ²=19.76, P=0.000); H. pylori antigens were located in the mucus layer and above the neck of the mucosal gland in 9 of 12 (75.0%) cases with chronic superficial gastritis, at the neck of the mucosal gland and the isthmus in 12 of 22 (54.5%) cases with precancerous changes, below the isthmus in 9 of 13 (69.2%) cases with gastric cancer (χ²=25.30, P=0.000). In the H.pylori negative group, no H. pylori antigen was observed. Conclusion: With the progression of chronic superficial gastritis→precancerous changes→gastric cancer, H. pylori antigens progressively migrated from the outer part to the inner part of the cell, and from the superficial to the deep gastric mucosa.

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