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Bio-Design and Manufacturing  2022 Vol.5 No.10 P.1304~1312

10.1631/jzus.2004.1304


Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection


Author(s):  TANG Jian-guo, LI Xuan, CHEN Ping

Affiliation(s):  Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   zhengzheng@mail.hz.zj.cn

Key Words:  Matrix metalloproteinase 9, EB virus, Nasopharyngeal carcinoma


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TANG Jian-guo, LI Xuan, CHEN Ping. Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection[J]. Journal of Zhejiang University Science D, 2022, 5(10): 1304~1312.

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author="TANG Jian-guo, LI Xuan, CHEN Ping",
journal="Journal of Zhejiang University Science D",
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number="10",
pages="1304~1312",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1304"
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%T Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection
%A TANG Jian-guo
%A LI Xuan
%A CHEN Ping
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 10
%P 1304~1312
%@ 1869-1951
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1304

TY - JOUR
T1 - Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection
A1 - TANG Jian-guo
A1 - LI Xuan
A1 - CHEN Ping
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 10
SP - 1304
EP - 1312
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1304


Abstract: 
Objective: To evaluate the expression of matrix metalloproteinase-9 (MMP9) in nasopharyngeal carcinoma and the association between MMP9 and Epstein-Barr virus infection. Methods: The MMP9 expression was studied by immunohistochemical analysis; and Epstein-Barr virus encoded small nuclear mRNA-1 (EBER-1) produced by in situ hybridization were examined in 41 nasopharyngeal carcinoma sections, and the relation between them, and the associations of MMP9 with clinical features were statistically analyzed. Results: Positive expression rate of MMP9 was 73.17%. The expression of MMP9 showed significant positive correlation with the expression of EBER-1 (γ=0.483, P=0.001). There was significant association of MMP9 expression with lymph nodes metastasis and clinical stage (P<0.001), non-significant association with age, gender, pathological classification and T classification. Conclusions: The highly pronounced expression of MMP9 is associated with cervical lymph nodes metastasis. Epstein-Barr virus can enhance NPC metastasis by up-regulating the expression of MMP9.

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Reference

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